(S)-2,2,3,3,10,10-hexamethyl-9,9-diphenyl-5-[(4S,6R)-2,2,6-trimethyl-1,3-dioxepan-4-yl]-4,8-dioxa-3,9-disilaundecane

Base Information

Chemical Name:(S)-2,2,3,3,10,10-hexamethyl-9,9-diphenyl-5-[(4S,6R)-2,2,6-trimethyl-1,3-dioxepan-4-yl]-4,8-dioxa-3,9-disilaundecane
CAS No.:1431372-86-9
Molecular Formula:C₃₃H₅₄O₄Si₂
Molecular Weight:570.96
Hs Code.:

Synonyms:(S)-2,2,3,3,10,10-hexamethyl-9,9-diphenyl-5-[(4S,6R)-2,2,6-trimethyl-1,3-dioxepan-4-yl]-4,8-dioxa-3,9-disilaundecane

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Chemical Property of (S)-2,2,3,3,10,10-hexamethyl-9,9-diphenyl-5-[(4S,6R)-2,2,6-trimethyl-1,3-dioxepan-4-yl]-4,8-dioxa-3,9-disilaundecane

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Technology Process of (S)-2,2,3,3,10,10-hexamethyl-9,9-diphenyl-5-[(4S,6R)-2,2,6-trimethyl-1,3-dioxepan-4-yl]-4,8-dioxa-3,9-disilaundecane

There total 8 articles about (S)-2,2,3,3,10,10-hexamethyl-9,9-diphenyl-5-[(4S,6R)-2,2,6-trimethyl-1,3-dioxepan-4-yl]-4,8-dioxa-3,9-disilaundecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1431372-85-8
(2R,4S,5S)-5-(tert-butyldimethylsilyloxy)-7-(tert-butyldiphenylsilyloxy)-2-methylheptane-1,4-diol

: 77-76-9
2,2-dimethoxy-propane

: 1431372-86-9
(S)-2,2,3,3,10,10-hexamethyl-9,9-diphenyl-5-[(4S,6R)-2,2,6-trimethyl-1,3-dioxepan-4-yl]-4,8-dioxa-3,9-disilaundecane

Guidance literature:: With camphor-10-sulfonic acid; In dichloromethane; at 0 - 20 ℃; for 0.5h;
DOI:10.1055/s-0032-1318141

Reference yield:

: 1015071-58-5
(3R,5S)-5-[(S)-2,2,3,3,10,10-hexamethyl-9,9-diphenyl-4,8-dioxa-3,9-disilaundecan-5-yl]-3-methyldihydrofuran-2(3H)-one

: 1431372-86-9
(S)-2,2,3,3,10,10-hexamethyl-9,9-diphenyl-5-[(4S,6R)-2,2,6-trimethyl-1,3-dioxepan-4-yl]-4,8-dioxa-3,9-disilaundecane

Guidance literature:: Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran; methanol / 0.5 h / 0 °C

2: camphor-10-sulfonic acid / dichloromethane / 0.5 h / 0 - 20 °C

With lithium borohydride; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-0032-1318141

Reference yield:

: 147977-33-1
(3R,S)-1-(tert-Butyldiphenylsilyloxy)pent-4-en-3-ol

: 1431372-86-9
(S)-2,2,3,3,10,10-hexamethyl-9,9-diphenyl-5-[(4S,6R)-2,2,6-trimethyl-1,3-dioxepan-4-yl]-4,8-dioxa-3,9-disilaundecane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4 h / Reflux

2.1: tert-butyl alcohol; AD-mix-α; methanesulfonamide / water / 24 h / 0 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

3.2: 1 h / -78 °C

4.1: lithium borohydride / tetrahydrofuran; methanol / 0.5 h / 0 °C

5.1: camphor-10-sulfonic acid / dichloromethane / 0.5 h / 0 - 20 °C

With lithium borohydride; methanesulfonamide; AD-mix-α; camphor-10-sulfonic acid; lithium hexamethyldisilazane; tert-butyl alcohol; In tetrahydrofuran; methanol; dichloromethane; water; 1.1: |Julia-Kocienski Olefination;
DOI:10.1055/s-0032-1318141