4-(4-carbamoyl-2-methoxyphenylamino)-6-(5-fluoropyridin-2-ylamino)-N-methyl-nicotinamide

Base Information

Chemical Name:4-(4-carbamoyl-2-methoxyphenylamino)-6-(5-fluoropyridin-2-ylamino)-N-methyl-nicotinamide
CAS No.:1609528-75-7
Molecular Formula:C₂₀H₁₉FN₆O₃
Molecular Weight:410.408
Hs Code.:

Synonyms:4-(4-carbamoyl-2-methoxyphenylamino)-6-(5-fluoropyridin-2-ylamino)-N-methyl-nicotinamide

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Chemical Property of 4-(4-carbamoyl-2-methoxyphenylamino)-6-(5-fluoropyridin-2-ylamino)-N-methyl-nicotinamide

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Technology Process of 4-(4-carbamoyl-2-methoxyphenylamino)-6-(5-fluoropyridin-2-ylamino)-N-methyl-nicotinamide

There total 5 articles about 4-(4-carbamoyl-2-methoxyphenylamino)-6-(5-fluoropyridin-2-ylamino)-N-methyl-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1609531-04-5
4-((2-((5-fluoropyridin-2-yl)amino)-5-(methylcarbamoyl)pyridin-4-yl)amino)-3-methoxybenzoic acid

: 1609528-75-7
4-(4-carbamoyl-2-methoxyphenylamino)-6-(5-fluoropyridin-2-ylamino)-N-methyl-nicotinamide

Guidance literature:: With ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 1609531-03-4
4-(2-chloro-5-(methylcarbamoyl)pyridin-4-ylamino)-3-methoxybenzoic acid

: 1609528-75-7
4-(4-carbamoyl-2-methoxyphenylamino)-6-(5-fluoropyridin-2-ylamino)-N-methyl-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl acetamide / 2 h / 145 °C / Inert atmosphere

2: ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 1609530-95-1
4,6-dichloro-N-methylnicotinamide

: 1609528-75-7
4-(4-carbamoyl-2-methoxyphenylamino)-6-(5-fluoropyridin-2-ylamino)-N-methyl-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl acetamide / 2 h

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl acetamide / 2 h / 145 °C / Inert atmosphere

3: ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;