4-((2-((5-fluoropyridin-2-yl)amino)-5-(methylcarbamoyl)pyridin-4-yl)amino)-3-methoxybenzoic acid

Base Information

Chemical Name:4-((2-((5-fluoropyridin-2-yl)amino)-5-(methylcarbamoyl)pyridin-4-yl)amino)-3-methoxybenzoic acid
CAS No.:1609531-04-5
Molecular Formula:C₂₀H₁₈FN₅O₄
Molecular Weight:411.392
Hs Code.:

Synonyms:4-((2-((5-fluoropyridin-2-yl)amino)-5-(methylcarbamoyl)pyridin-4-yl)amino)-3-methoxybenzoic acid

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Chemical Property of 4-((2-((5-fluoropyridin-2-yl)amino)-5-(methylcarbamoyl)pyridin-4-yl)amino)-3-methoxybenzoic acid

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Technology Process of 4-((2-((5-fluoropyridin-2-yl)amino)-5-(methylcarbamoyl)pyridin-4-yl)amino)-3-methoxybenzoic acid

There total 4 articles about 4-((2-((5-fluoropyridin-2-yl)amino)-5-(methylcarbamoyl)pyridin-4-yl)amino)-3-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1609531-03-4
4-(2-chloro-5-(methylcarbamoyl)pyridin-4-ylamino)-3-methoxybenzoic acid

: 21717-96-4
2-amino-5-fluoropyridine

: 1609531-04-5
4-((2-((5-fluoropyridin-2-yl)amino)-5-(methylcarbamoyl)pyridin-4-yl)amino)-3-methoxybenzoic acid

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl acetamide; at 145 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1609530-95-1
4,6-dichloro-N-methylnicotinamide

: 1609531-04-5
4-((2-((5-fluoropyridin-2-yl)amino)-5-(methylcarbamoyl)pyridin-4-yl)amino)-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl acetamide / 2 h

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl acetamide / 2 h / 145 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 2486-69-3
3-methoxy-4-aminobenzoic acid

: 1609531-04-5
4-((2-((5-fluoropyridin-2-yl)amino)-5-(methylcarbamoyl)pyridin-4-yl)amino)-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl acetamide / 2 h

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl acetamide / 2 h / 145 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; N,N-dimethyl acetamide;