diethyl 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido) propan-2-yl)pyridin-2-yl)phenylphosphonate

Base Information

Chemical Name:diethyl 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido) propan-2-yl)pyridin-2-yl)phenylphosphonate
CAS No.:1436433-35-0
Molecular Formula:C₂₇H₂₉N₆O₅P
Molecular Weight:548.538
Hs Code.:

Synonyms:diethyl 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido) propan-2-yl)pyridin-2-yl)phenylphosphonate

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Chemical Property of diethyl 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido) propan-2-yl)pyridin-2-yl)phenylphosphonate

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Technology Process of diethyl 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido) propan-2-yl)pyridin-2-yl)phenylphosphonate

There total 14 articles about diethyl 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido) propan-2-yl)pyridin-2-yl)phenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1187992-93-3
4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxylic acid

: 1428527-63-2
diethyl 4-(5-(2-aminopropan-2-yl)pyridin-2-yl)phenylphosphonate

: 1436433-35-0
diethyl 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido) propan-2-yl)pyridin-2-yl)phenylphosphonate

Guidance literature:: 4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxylic acid; With thionyl chloride; at 60 ℃; for 4h;

diethyl 4-(5-(2-aminopropan-2-yl)pyridin-2-yl)phenylphosphonate; With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1345019-59-1
C₉H₅ClN₄O₂

: 1428527-63-2
diethyl 4-(5-(2-aminopropan-2-yl)pyridin-2-yl)phenylphosphonate

: 1436433-35-0
diethyl 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido) propan-2-yl)pyridin-2-yl)phenylphosphonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 5h;

Reference yield:

: 106861-14-7
2-[(4-methylphenyl)sulfonyl]-2,3-dihydropyridazine-3-carbonitrile

: 1436433-35-0
diethyl 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido) propan-2-yl)pyridin-2-yl)phenylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.1: sodium methylate / methanol / 20 °C

2.2: 3 h / Reflux

3.1: sodium methylate / methanol / Reflux

3.2: 4 h / Reflux

4.1: thionyl chloride / Reflux

5.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C

With thionyl chloride; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; dichloromethane;