4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)pyridine-2-yl)phenylphosphonic acid

Base Information

Chemical Name:4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)pyridine-2-yl)phenylphosphonic acid
CAS No.:1428527-66-5
Molecular Formula:C₂₃H₂₁N₆O₅P
Molecular Weight:492.431
Hs Code.:

Synonyms:4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)pyridine-2-yl)phenylphosphonic acid

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Chemical Property of 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)pyridine-2-yl)phenylphosphonic acid

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Technology Process of 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)pyridine-2-yl)phenylphosphonic acid

There total 15 articles about 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)pyridine-2-yl)phenylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1436433-35-0
diethyl 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido) propan-2-yl)pyridin-2-yl)phenylphosphonate

: 1428527-66-5
4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)pyridine-2-yl)phenylphosphonic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 53896-49-4
pyridazine-3-carbonitrile

: 1428527-66-5
4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)pyridine-2-yl)phenylphosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 20 °C

1.2: 3 h / Reflux

2.1: sodium methylate / methanol / Reflux

2.2: 4 h / Reflux

3.1: thionyl chloride / Reflux

4.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C

5.1: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

With thionyl chloride; trimethylsilyl bromide; sodium methylate; triethylamine; In methanol; dichloromethane;

Reference yield:

: 106861-14-7
2-[(4-methylphenyl)sulfonyl]-2,3-dihydropyridazine-3-carbonitrile

: 1428527-66-5
4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)pyridine-2-yl)phenylphosphonic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.1: sodium methylate / methanol / 20 °C

2.2: 3 h / Reflux

3.1: sodium methylate / methanol / Reflux

3.2: 4 h / Reflux

4.1: thionyl chloride / Reflux

5.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C

6.1: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

With thionyl chloride; trimethylsilyl bromide; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; dichloromethane;