3'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{O^P-[2-(4-nitrophenyl)ethyl]}->5')-3'-deoxy-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine

Base Information

• Chemical Name: 3'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{O^P-[2-(4-nitrophenyl)ethyl]}->5')-3'-deoxy-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine
• CAS No.: 179397-60-5
• Molecular Formula: C₆₆H₆₂N₁₃O₁₉P
• Molecular Weight: 1372.27
• Mol file: 179397-60-5.mol

Synonyms:3'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{O^P-[2-(4-nitrophenyl)ethyl]}->5')-3'-deoxy-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine

Chemical Property of 3'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{O^P-[2-(4-nitrophenyl)ethyl]}->5')-3'-deoxy-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{O^P-[2-(4-nitrophenyl)ethyl]}->5')-3'-deoxy-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine

There total 1 articles about 3'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{O^P-[2-(4-nitrophenyl)ethyl]}->5')-3'-deoxy-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{OP-[2-(4-nitrophenyl)ethyl]}->5')-2'-O-acetyl-3'-deoxy-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine (179397-59-2) → 3'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{OP-[2-(4-nitrophenyl)ethyl]}->5')-3'-deoxy-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine (179397-60-5)

Guidance literature:

With potassium carbonate; In methanol; dichloromethane; for 3h; Ambient temperature;

DOI:10.1002/hlca.19960790314

Reference yield:

3'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{OP-[2-(4-nitrophenyl)ethyl]}->5')-3'-deoxy-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine (179397-60-5) + Acetic acid 2-{(2R,3R,4R,5R)-2-{diisopropylamino-[2-(4-nitro-phenyl)-ethoxy]-phosphanyloxymethyl}-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester (179397-58-1) → 3'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{OP-[2-(4-nitrophenyl)ethyl]}->5)-3'-deoxy-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{OP-[2-(4-nitrophenyl)ethyl]}->5')-3'-O-(2-acetoxyeth...

Guidance literature:

With 1H-tetrazole; iodine; Yield given. Multistep reaction; 1.) MeCN, r.t., 2 h; 2.) pyridine, CH₂Cl₂, H₂O;

DOI:10.1002/hlca.19960790314

upstream raw materials:

3'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{O^P-[2-(4-nitrophenyl)ethyl]}->5')-2'-O-acetyl-3'-deoxy-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine