2,3-Butanediol, 2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-, (2R,3R)- (2R,3R)-2-(2,5-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol

Base Information

Chemical Name:2,3-Butanediol, 2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-, (2R,3R)- (2R,3R)-2-(2,5-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol
CAS No.:241479-72-1
Molecular Formula:C₁₂H₁₃F₂N₃O₂
Molecular Weight:269.251
Hs Code.:
Mol file:241479-72-1.mol

Synonyms:(2R,3R)-2-(2,5-difluoro-phenyl)-1-(1H-1,2,4-triazole-1-yl)butan-2,3-diol

Suppliers and Price of 2,3-Butanediol, 2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-, (2R,3R)- (2R,3R)-2-(2,5-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(2R,3R)-2-(2,5-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol 95+%
1g
$ 842.00

Alichem
(2R,3R)-2-(2,5-Difluorophenyl)-1-(1h-1,2,4-triazol-1-yl)butane-2,3-diol
1g
$ 868.15

Total 21 raw suppliers

Chemical Property of 2,3-Butanediol, 2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-, (2R,3R)- (2R,3R)-2-(2,5-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol

Chemical Property:

Boiling Point:485.0±55.0 °C(Predicted)
PKA:11.94±0.29(Predicted)
Density:1.38±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(2R,3R)-2-(2,5-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Des-4-methylenepiperidine Efinaconazole is an impurity of Efinaconazole (E435070(P)). Efinaconazole is a topical antifungal for onychomycosis. (Synonyms: KP-103)

Technology Process of 2,3-Butanediol, 2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-, (2R,3R)- (2R,3R)-2-(2,5-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol

There total 16 articles about 2,3-Butanediol, 2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-, (2R,3R)- (2R,3R)-2-(2,5-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (S)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-one

: 241479-72-1
(2R,3R)-2-(2,5-difluoro-phenyl)-1-(1H-1,2,4-triazole-1-yl)butan-2,3-diol

Guidance literature:: (S)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-one; With cobalt(II) chloride; In tetrahydrofuran; at 30 ℃; for 0.333333h;

With lithium borohydride; In tetrahydrofuran; at -78 ℃; for 4h; enantioselective reaction;
DOI:10.1021/acs.orglett.1c02588

Reference yield: 93.0%

: (S)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-one

: 241479-72-1
(2R,3R)-2-(2,5-difluoro-phenyl)-1-(1H-1,2,4-triazole-1-yl)butan-2,3-diol

: 2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol

Guidance literature:: (S)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-one; With cobalt(II) chloride; In tetrahydrofuran; at 30 ℃; for 0.333333h;

With lithium borohydride; zinc(II) chloride; In tetrahydrofuran; at -78 ℃; for 4h; Reagent/catalyst; Solvent; Temperature; enantioselective reaction;
DOI:10.1021/acs.orglett.1c02588