1-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)cyclopropanecarboxamide

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Chemical Name:1-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)cyclopropanecarboxamide
CAS No.:1346264-31-0
Molecular Formula:C₁₆H₁₂F₃N₅O
Molecular Weight:347.299
Hs Code.:

Synonyms:1-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)cyclopropanecarboxamide

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Chemical Property of 1-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)cyclopropanecarboxamide

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Technology Process of 1-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)cyclopropanecarboxamide

There total 6 articles about 1-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1346264-34-3
1-[3-[1-tert-butyl-1-3-(trifluoromethyl)pyrazolo[3,4-d]pyrimidin-4-yl]phenyl]cyclopropanecarbonitrile

: 1346264-31-0
1-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)cyclopropanecarboxamide

Guidance literature:: 1-[3-[1-tert-butyl-1-3-(trifluoromethyl)pyrazolo[3,4-d]pyrimidin-4-yl]phenyl]cyclopropanecarbonitrile; With methanesulfonic acid; at 60 ℃; for 2h;

With sodium hydrogencarbonate; at 20 ℃; pH=8;

Reference yield:

: 871338-41-9
ethyl 5-amino-1-(tert-butyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1346264-31-0
1-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetonitrile / 5 h / 50 °C

2.1: ammonia / methanol / 100 - 165 °C

2.2: 48 h / 180 °C / Molecular sieve

3.1: thionyl chloride / N,N-dimethyl-formamide / 16 h / 77 °C

4.1: sodium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 5 h / 67 °C / Inert atmosphere

5.1: methanesulfonic acid / 2 h / 60 °C

5.2: 20 °C / pH 8

With thionyl chloride; methanesulfonic acid; ammonia; sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; acetonitrile;

Reference yield:

: 871338-42-0
1-(tert-butyl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol

: 1346264-31-0
1-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 16 h / 77 °C

2.1: sodium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 5 h / 67 °C / Inert atmosphere

3.1: methanesulfonic acid / 2 h / 60 °C

3.2: 20 °C / pH 8

With thionyl chloride; methanesulfonic acid; sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; N,N-dimethyl-formamide; In 1,4-dioxane;