1-[3-[1-tert-butyl-1-3-(trifluoromethyl)pyrazolo[3,4-d]pyrimidin-4-yl]phenyl]cyclopropanecarbonitrile

Base Information

Chemical Name:1-[3-[1-tert-butyl-1-3-(trifluoromethyl)pyrazolo[3,4-d]pyrimidin-4-yl]phenyl]cyclopropanecarbonitrile
CAS No.:1346264-34-3
Molecular Formula:C₂₀H₁₈F₃N₅
Molecular Weight:385.392
Hs Code.:

Synonyms:1-[3-[1-tert-butyl-1-3-(trifluoromethyl)pyrazolo[3,4-d]pyrimidin-4-yl]phenyl]cyclopropanecarbonitrile

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Chemical Property of 1-[3-[1-tert-butyl-1-3-(trifluoromethyl)pyrazolo[3,4-d]pyrimidin-4-yl]phenyl]cyclopropanecarbonitrile

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Technology Process of 1-[3-[1-tert-butyl-1-3-(trifluoromethyl)pyrazolo[3,4-d]pyrimidin-4-yl]phenyl]cyclopropanecarbonitrile

There total 5 articles about 1-[3-[1-tert-butyl-1-3-(trifluoromethyl)pyrazolo[3,4-d]pyrimidin-4-yl]phenyl]cyclopropanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 871338-43-1
1-(tert-butyl)-4-chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidine

: 1346264-25-2
1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarbonitrile

: 1346264-34-3
1-[3-[1-tert-butyl-1-3-(trifluoromethyl)pyrazolo[3,4-d]pyrimidin-4-yl]phenyl]cyclopropanecarbonitrile

Guidance literature:: With sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; at 67 ℃; for 5h; Inert atmosphere;

Reference yield:

: 871338-41-9
ethyl 5-amino-1-(tert-butyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1346264-34-3
1-[3-[1-tert-butyl-1-3-(trifluoromethyl)pyrazolo[3,4-d]pyrimidin-4-yl]phenyl]cyclopropanecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / 5 h / 50 °C

2.1: ammonia / methanol / 100 - 165 °C

2.2: 48 h / 180 °C / Molecular sieve

3.1: thionyl chloride / N,N-dimethyl-formamide / 16 h / 77 °C

4.1: sodium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 5 h / 67 °C / Inert atmosphere

With thionyl chloride; ammonia; sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; acetonitrile;

Reference yield:

: 871338-42-0
1-(tert-butyl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol

: 1346264-34-3
1-[3-[1-tert-butyl-1-3-(trifluoromethyl)pyrazolo[3,4-d]pyrimidin-4-yl]phenyl]cyclopropanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / 16 h / 77 °C

2: sodium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 5 h / 67 °C / Inert atmosphere

With thionyl chloride; sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; N,N-dimethyl-formamide; In 1,4-dioxane;