(3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid phenylmethyl ester

Base Information

Chemical Name:(3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid phenylmethyl ester
CAS No.:1055423-27-2
Molecular Formula:C₁₉H₂₆N₂O₅
Molecular Weight:362.426
Hs Code.:

Synonyms:(3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid phenylmethyl ester

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Chemical Property of (3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid phenylmethyl ester

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Technology Process of (3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid phenylmethyl ester

There total 2 articles about (3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 1055423-27-2
(3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid phenylmethyl ester

Guidance literature:: With Succinimide; dicyclohexyl-carbodiimide; In ethyl acetate; at 20 ℃; for 5h;
DOI:10.1021/ja0670761

Reference yield:

: 1055423-27-2
(3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid phenylmethyl ester

Guidance literature:

Reference yield:

: 1055423-27-2
(3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid phenylmethyl ester

: 918437-67-9
7-benzyl-1-tert-butoxycarbonyl-1,7-diaza-spiro[4,6]undec-6-one

Guidance literature:: Multi-step reaction with 7 steps

1: 74 g / H₂ / Pd-C / ethyl acetate / 8 h

2: 75 percent / potassium hexamethyldisilazide / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C

3: HCl / ethyl acetate / 1.5 h / 20 °C

4: K₂CO₃; NaI / dimethylformamide / 2 h / 70 °C

5: 748 mg / diisopropylethylamine / CH₂Cl₂ / 11 h / 20 °C

6: 77 percent / carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 1 h / 0 °C

7: 72 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / 20 °C

With hydrogenchloride; carbon tetrabromide; hydrogen; sodium hexamethyldisilazane; potassium hexamethylsilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja0670761