4-ethyl-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Base Information

Chemical Name:4-ethyl-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one
CAS No.:1446712-52-2
Molecular Formula:C₂₄H₂₁F₂N₅O
Molecular Weight:433.46
Hs Code.:

Synonyms:4-ethyl-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Chemical Property of 4-ethyl-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Technology Process of 4-ethyl-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

There total 3 articles about 4-ethyl-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426309-20-7
2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

: 544-97-8
dimethyl zinc(II)

: 1446712-52-2
4-ethyl-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; toluene; at 20 - 90 ℃; Inert atmosphere;

Reference yield:

: 1228788-10-0
methyl 3,3-dicyano-2,2-dimethylpropanoate

: 1446712-52-2
4-ethyl-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tert-butyl alcohol / 18 h / Reflux

2: isopentyl nitrite; diiodomethane / 85 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; toluene; dichloromethane / 20 - 90 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diiodomethane; potassium tert-butylate; isopentyl nitrite; In 1,4-dioxane; dichloromethane; toluene; tert-butyl alcohol;

Reference yield:

: 451-82-1
(2-fluorophenyl)acetic acid

: 1446712-52-2
4-ethyl-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.83 h / -70 - 0 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: boron trifluoride diethyl etherate / ethylene glycol / 5 h / 120 °C

3.1: copper(l) iodide / 1-methyl-pyrrolidin-2-one / 0.23 h / 170 °C

3.2: 0.25 h / Cooling with ice

4.1: potassium tert-butylate / tert-butyl alcohol / 18 h / Reflux

5.1: isopentyl nitrite; diiodomethane / 85 °C

6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; toluene; dichloromethane / 20 - 90 °C / Inert atmosphere

With copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diiodomethane; boron trifluoride diethyl etherate; potassium tert-butylate; sodium hexamethyldisilazane; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; ethylene glycol; toluene; tert-butyl alcohol;