1-((4S)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl))-(2S,3R)-2-azido-3-(4-((bis-(tert-butyl)phosphono)methyl)phenyl)-6-(1,1,2,2-tetramethyl-1-silapropoxy)hexan-1-one

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Chemical Name:1-((4S)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl))-(2S,3R)-2-azido-3-(4-((bis-(tert-butyl)phosphono)methyl)phenyl)-6-(1,1,2,2-tetramethyl-1-silapropoxy)hexan-1-one
CAS No.:525575-16-0
Molecular Formula:C₃₇H₅₇N₄O₇PSi
Molecular Weight:728.941
Hs Code.:

Synonyms:1-((4S)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl))-(2S,3R)-2-azido-3-(4-((bis-(tert-butyl)phosphono)methyl)phenyl)-6-(1,1,2,2-tetramethyl-1-silapropoxy)hexan-1-one

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Chemical Property of 1-((4S)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl))-(2S,3R)-2-azido-3-(4-((bis-(tert-butyl)phosphono)methyl)phenyl)-6-(1,1,2,2-tetramethyl-1-silapropoxy)hexan-1-one

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Technology Process of 1-((4S)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl))-(2S,3R)-2-azido-3-(4-((bis-(tert-butyl)phosphono)methyl)phenyl)-6-(1,1,2,2-tetramethyl-1-silapropoxy)hexan-1-one

There total 5 articles about 1-((4S)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl))-(2S,3R)-2-azido-3-(4-((bis-(tert-butyl)phosphono)methyl)phenyl)-6-(1,1,2,2-tetramethyl-1-silapropoxy)hexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 525575-15-9
(4S)-3-((3S)-3-(4-((bis-(tert-butyl)phosphono)methyl)phenyl)-6-(1,1,2,2-tetramethyl-1-silapropoxy)hexanoyl)-4-benzyl-1,3-oxazolidin-2-one

: 525575-16-0
1-((4S)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl))-(2S,3R)-2-azido-3-(4-((bis-(tert-butyl)phosphono)methyl)phenyl)-6-(1,1,2,2-tetramethyl-1-silapropoxy)hexan-1-one

Guidance literature:: (4S)-3-((3S)-3-(4-((bis-(tert-butyl)phosphono)methyl)phenyl)-6-(1,1,2,2-tetramethyl-1-silapropoxy)hexanoyl)-4-benzyl-1,3-oxazolidin-2-one; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.666667h;

With 2,4,6-Triisopropylbenzenesulfonyl azide; In tetrahydrofuran; at -78 ℃; for 0.0333333h;
DOI:10.1016/S0040-4020(02)01421-7

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 525575-16-0
1-((4S)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl))-(2S,3R)-2-azido-3-(4-((bis-(tert-butyl)phosphono)methyl)phenyl)-6-(1,1,2,2-tetramethyl-1-silapropoxy)hexan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 82 percent / imidazole / dimethylformamide / 20 °C

2.1: KHMDS / tetrahydrofuran; toluene / 0.67 h / -78 °C

2.2: 35 percent / trisyl azide / tetrahydrofuran / 0.03 h / -78 °C

With 1H-imidazole; potassium hexamethylsilazane; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(02)01421-7

Reference yield:

: 3-(3-(4-((bis(tert-butyl)phosphono)methyl)phenyl)prop-2-enoyl)-4(S)-benzyl-1,3-oxazolidin-2-one

: 525575-16-0
1-((4S)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl))-(2S,3R)-2-azido-3-(4-((bis-(tert-butyl)phosphono)methyl)phenyl)-6-(1,1,2,2-tetramethyl-1-silapropoxy)hexan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 80 percent / CuBr*SMe₂ / tetrahydrofuran / 2.5 h / -78 °C

2.1: BH₃ / tetrahydrofuran / 1 h / 0 °C

2.2: 90 percent / NaBO₃*H₂O / tetrahydrofuran; H₂O / 3 h / 20 °C

3.1: 82 percent / imidazole / dimethylformamide / 20 °C

4.1: KHMDS / tetrahydrofuran; toluene / 0.67 h / -78 °C

4.2: 35 percent / trisyl azide / tetrahydrofuran / 0.03 h / -78 °C

With 1H-imidazole; copper(I) bromide dimethylsulfide complex; borane; potassium hexamethylsilazane; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 1.1: Michael addition;
DOI:10.1016/S0040-4020(02)01421-7