C₂₁H₂₆N₂O₅

Base Information

• Chemical Name: C₂₁H₂₆N₂O₅
• CAS No.: 1438020-91-7
• Molecular Formula: C₂₁H₂₆N₂O₅
• Molecular Weight: 386.448
• Mol file: 1438020-91-7.mol

Synonyms:C₂₁H₂₆N₂O₅

Chemical Property of C₂₁H₂₆N₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₆N₂O₅

There total 6 articles about C₂₁H₂₆N₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C25H34N2O5 (1438020-76-8) → C21H26N2O5 (1438020-91-7)

Guidance literature:

With hydrogenchloride; trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 12h;

DOI:10.1021/ja4025148

Reference yield:

C13H17NO6 (1438020-61-1) → C21H26N2O5 (1438020-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 70 °C

1.2: 12 h / 20 °C

2.1: trifluoroacetic acid; hydrogenchloride / dichloromethane; water / 12 h / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ja4025148

Reference yield:

methyl 3-oxo-2-oximinobutanoate (73708-95-9) → C21H26N2O5 (1438020-91-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium acetate; acetic acid; zinc / 2 h / 60 - 90 °C

2.1: acetic acid; bromine; sulfuryl dichloride / 5 h / 10 - 20 °C

2.2: 1 h / 20 °C

3.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 12 h

4.1: palladium 10% on activated carbon; formic acid; hydrogen / methanol / 2 h

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 70 °C

5.2: 12 h / 20 °C

6.1: trifluoroacetic acid; hydrogenchloride / dichloromethane; water / 12 h / 20 °C

With hydrogenchloride; dmap; formic acid; sulfuryl dichloride; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; bromine; sodium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ja4025148

upstream raw materials:

C₂₀H₂₃NO₆

C₁₃H₁₇NO₆

C₁₆H₁₇NO₄

methyl 3-oxo-2-oximinobutanoate

Downstream raw materials:

C₂₇H₃₇N₅O₆

C₂₂H₂₉N₅O₄*ClH

C₂₁H₂₇N₅O₄