METHYL-3-OXO-2-OXIMINOBUTYRATE

Base Information

• Chemical Name: METHYL-3-OXO-2-OXIMINOBUTYRATE
• CAS No.: 73708-95-9
• Molecular Formula: C5H7 N O4
• Molecular Weight: 145.115
• Mol file: 73708-95-9.mol

Synonyms:Butyricacid, 2,3-dioxo-, methyl ester, 2-oxime (6CI); 2-Hydroxyimino-3-oxobutanoicacid methyl ester; Methyl 2-(hydroxyimino)-3-oxobutanoate; Methyl2-(hydroxyimino)acetoacetate; Methyl 3-oxo-2-(hydroxyimino)butanoate

Chemical Property of METHYL-3-OXO-2-OXIMINOBUTYRATE

Chemical Property:

• PSA: 75.96000
• LogP: -0.42140

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-Oxo-2-(hydroxyimino)butanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 3-Oxo-2-(hydroxyimino)butanoate is an intermediate in synthesizing Desfuroyl Ceftiofur Cysteine Disulfide-d3 (), a labelled Desfuroyl Ceftiofur-related metabolite that have the potential to be microbiologic active in swine muscle, kidney, liver and fat.

Technology Process of METHYL-3-OXO-2-OXIMINOBUTYRATE

There total 2 articles about METHYL-3-OXO-2-OXIMINOBUTYRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acetoacetic acid methyl ester (105-45-3) → methyl 3-oxo-2-oximinobutanoate (73708-95-9)

Guidance literature:

acetoacetic acid methyl ester; With acetic acid; sodium nitrite; In water; at 0 - 20 ℃; for 2h;

With water; for 0.5h;

DOI:10.1039/c9ob00554d

Reference yield: 93.0%

methyl 2-(benzyloxyimino)-3-oxobutanoate (84187-51-9) → methyl 3-oxo-2-oximinobutanoate (73708-95-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water; acetic acid; at 20 ℃;

DOI:10.1246/bcsj.77.1407

Reference yield: 84.0%

methyl 3-oxo-2-oximinobutanoate (73708-95-9) + 4-methyl-benzaldehyde (104-87-0) → 5-methyl-3-oxy-2-p-tolyl-oxazole-4-carboxylic acid methyl ester (851181-41-4)

Guidance literature:

With hydrogenchloride; In acetic acid; at 0 ℃; for 2h;

upstream raw materials:

acetoacetic acid methyl ester

methyl 2-(benzyloxyimino)-3-oxobutanoate

Downstream raw materials:

2-amino-3-oxo-butyric acid methyl ester

methyl 2-acetamido-3-oxobutanoate

2-Cinnamoylamino-acetessigsaeure-methylester

2-Phenylacetylamino-acetessigsaeure-methylester