N,N,N',N'-tetramethyl-(2-(3-tert-butyl(dimethyl)siloxy)propyl)phenylphosphonothioic diamide

Base Information

Chemical Name:N,N,N',N'-tetramethyl-(2-(3-tert-butyl(dimethyl)siloxy)propyl)phenylphosphonothioic diamide
CAS No.:1313031-96-7
Molecular Formula:C₁₉H₃₇N₂OPSSi
Molecular Weight:400.641
Hs Code.:

Synonyms:N,N,N',N'-tetramethyl-(2-(3-tert-butyl(dimethyl)siloxy)propyl)phenylphosphonothioic diamide

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Chemical Property of N,N,N',N'-tetramethyl-(2-(3-tert-butyl(dimethyl)siloxy)propyl)phenylphosphonothioic diamide

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Technology Process of N,N,N',N'-tetramethyl-(2-(3-tert-butyl(dimethyl)siloxy)propyl)phenylphosphonothioic diamide

There total 2 articles about N,N,N',N'-tetramethyl-(2-(3-tert-butyl(dimethyl)siloxy)propyl)phenylphosphonothioic diamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 3732-85-2
N,N,N',N'-tetramethyl-P-phenylphosphonothioic diamide

: 89031-84-5
3-(tert-butyldimethylsilyloxy)propyl bromide

: 1313031-96-7
N,N,N',N'-tetramethyl-(2-(3-tert-butyl(dimethyl)siloxy)propyl)phenylphosphonothioic diamide

Guidance literature:: N,N,N',N'-tetramethyl-P-phenylphosphonothioic diamide; With n-butyllithium; In diethyl ether; hexane; at 20 ℃; for 16h; Inert atmosphere;

3-(tert-butyldimethylsilyloxy)propyl bromide; In diethyl ether; hexane; Inert atmosphere; Reflux;
DOI:10.1002/chir.20702

Reference yield:

: 3497-00-5
phenylthiophosphonic acid dichloride

: 1313031-96-7
N,N,N',N'-tetramethyl-(2-(3-tert-butyl(dimethyl)siloxy)propyl)phenylphosphonothioic diamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 3.75 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / diethyl ether; hexane / 16 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere; Reflux

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1002/chir.20702

Reference yield:

: 1313031-96-7
N,N,N',N'-tetramethyl-(2-(3-tert-butyl(dimethyl)siloxy)propyl)phenylphosphonothioic diamide

: C₉H₁₁O₂PS*C₁₄H₁₅NO

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

2.1: sodium isopropanethiolate / tetrahydrofuran / 6 h / Reflux; Inert atmosphere

2.2: Inert atmosphere

3.1: potassium hydroxide / Inert atmosphere

3.2: pH 1 / Inert atmosphere

4.1: ethanol; water / Resolution of racemate; Inert atmosphere

With hydrogenchloride; sodium isopropanethiolate; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water;
DOI:10.1002/chir.20702