[(S)-3-Phenyl-2-(2-{(S)-3-phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-acetylamino)-propionylamino]-acetic acid methyl ester; hydrochloride

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Chemical Name:[(S)-3-Phenyl-2-(2-{(S)-3-phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-acetylamino)-propionylamino]-acetic acid methyl ester; hydrochloride
CAS No.:82247-66-3
Molecular Formula:C₂₈H₃₅N₅O₆*ClH
Molecular Weight:574.077
Hs Code.:

[(S)-3-Phenyl-2-(2-{(S)-3-phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-acetylamino)-propionylamino]-acetic acid methyl ester; hydrochloride

Synonyms:[(S)-3-Phenyl-2-(2-{(S)-3-phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-acetylamino)-propionylamino]-acetic acid methyl ester; hydrochloride

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Chemical Property of [(S)-3-Phenyl-2-(2-{(S)-3-phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-acetylamino)-propionylamino]-acetic acid methyl ester; hydrochloride

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Technology Process of [(S)-3-Phenyl-2-(2-{(S)-3-phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-acetylamino)-propionylamino]-acetic acid methyl ester; hydrochloride

There total 3 articles about [(S)-3-Phenyl-2-(2-{(S)-3-phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-acetylamino)-propionylamino]-acetic acid methyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 82265-53-0
(S)-2-[(S)-1-({[(S)-1-(Methoxycarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 82247-66-3
[(S)-3-Phenyl-2-(2-{(S)-3-phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-acetylamino)-propionylamino]-acetic acid methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 2h;
DOI:10.1021/ja00381a006

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 82247-66-3
[(S)-3-Phenyl-2-(2-{(S)-3-phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-acetylamino)-propionylamino]-acetic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / dicyclohexycarbodiimide, N-hydroxybenzotriazole, N-methylmorpholine

2: 91 percent / 2N HCl / dioxane / 2 h

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane;
DOI:10.1021/ja00381a006

Reference yield:

: 66876-51-5
{(S)-2-[2-((S)-2-Amino-3-phenyl-propionylamino)-acetylamino]-3-phenyl-propionylamino}-acetic acid methyl ester; hydrochloride

: 82247-66-3
[(S)-3-Phenyl-2-(2-{(S)-3-phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-acetylamino)-propionylamino]-acetic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / dicyclohexycarbodiimide, N-hydroxybenzotriazole, N-methylmorpholine

2: 91 percent / 2N HCl / dioxane / 2 h

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane;
DOI:10.1021/ja00381a006