(S)-2-[(S)-1-({[(S)-1-(Methoxycarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (S)-2-[(S)-1-({[(S)-1-(Methoxycarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS No.: 82265-53-0
• Molecular Formula: C₃₃H₄₃N₅O₈
• Molecular Weight: 637.733

Synonyms:(S)-2-[(S)-1-({[(S)-1-(Methoxycarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property of (S)-2-[(S)-1-({[(S)-1-(Methoxycarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of (S)-2-[(S)-1-({[(S)-1-(Methoxycarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 1 articles about (S)-2-[(S)-1-({[(S)-1-(Methoxycarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + {(S)-2-[2-((S)-2-Amino-3-phenyl-propionylamino)-acetylamino]-3-phenyl-propionylamino}-acetic acid methyl ester; hydrochloride (66876-51-5) → (S)-2-[(S)-1-({[(S)-1-(Methoxycarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (82265-53-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide;

DOI:10.1021/ja00381a006

Reference yield: 91.0%

(S)-2-[(S)-1-({[(S)-1-(Methoxycarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (82265-53-0) → [(S)-3-Phenyl-2-(2-{(S)-3-phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-acetylamino)-propionylamino]-acetic acid methyl ester; hydrochloride (82247-66-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 2h;

DOI:10.1021/ja00381a006

Reference yield: 81.0%

(S)-2-[(S)-1-({[(S)-1-(Methoxycarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (82265-53-0) → (S)-2-[(S)-1-({[(S)-1-(Hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (82265-54-1)

Guidance literature:

With hydrazine hydrate; In methanol; at 40 ℃; for 2h;

DOI:10.1021/ja00381a006

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

{(S)-2-[2-((S)-2-Amino-3-phenyl-propionylamino)-acetylamino]-3-phenyl-propionylamino}-acetic acid methyl ester; hydrochloride

Downstream raw materials:

(S)-2-[(S)-1-({[(S)-1-(Hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

[(S)-3-Phenyl-2-(2-{(S)-3-phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-acetylamino)-propionylamino]-acetic acid methyl ester; hydrochloride

(S)-Pyrrolidine-2-carboxylic acid [(S)-1-({[(S)-1-(hydrazinocarbonylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-amide; hydrochloride

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