[(4R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,2,6-trimethyl-cyclohex-(Z)-ylidene]-hydrazine

Base Information

• Chemical Name: [(4R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,2,6-trimethyl-cyclohex-(Z)-ylidene]-hydrazine
• CAS No.: 444122-12-7
• Molecular Formula: C₁₅H₃₂N₂OSi
• Molecular Weight: 284.517
• Mol file: 444122-12-7.mol

Synonyms:[(4R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,2,6-trimethyl-cyclohex-(Z)-ylidene]-hydrazine

Chemical Property of [(4R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,2,6-trimethyl-cyclohex-(Z)-ylidene]-hydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(4R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,2,6-trimethyl-cyclohex-(Z)-ylidene]-hydrazine

There total 4 articles about [(4R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,2,6-trimethyl-cyclohex-(Z)-ylidene]-hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4R,6R)-4-[(tert-butyldimethylsilyl)oxy]-2,2,6-trimethylcyclohexan-1-one (130583-95-8) → [(4R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,2,6-trimethyl-cyclohex-(Z)-ylidene]-hydrazine (444122-12-7)

Guidance literature:

With hydrazine hydrate; triethylamine; In ethanol; at 100 ℃; for 24h;

DOI:10.1021/jo025727f

Reference yield:

(4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexan-1-one (20548-02-1,55058-51-0,60686-81-9,60686-82-0,82977-53-5,90082-06-7,90129-05-8,99881-84-2,60046-50-6) → [(4R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,2,6-trimethyl-cyclohex-(Z)-ylidene]-hydrazine (444122-12-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / imidazole / dimethylformamide / 6 h / 0 °C

2: NH₂NH₂*H₂O; Et₃N / ethanol / 24 h / 100 °C

With 1H-imidazole; hydrazine hydrate; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jo025727f

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → [(4R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2,2,6-trimethyl-cyclohex-(Z)-ylidene]-hydrazine (444122-12-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / imidazole / dimethylformamide / 6 h / 0 °C

2: NH₂NH₂*H₂O; Et₃N / ethanol / 24 h / 100 °C

With 1H-imidazole; hydrazine hydrate; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jo025727f

upstream raw materials:

(4R,6R)-4-[(tert-butyldimethylsilyl)oxy]-2,2,6-trimethylcyclohexan-1-one

(4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexan-1-one

tert-butyldimethylsilyl chloride

Downstream raw materials:

tert-butyldimethylsilyl (R)-4-iodo-3,5,5-trimethylcyclohex-3-en-1-yl ether

(S,E)-4-[4-(tert-butyldimethylsilyloxy)-2,6,6-trimethylcyclohex-1-en-1-yl]but-3-en-2-one

(S)-4-[(E)-but-1-en-3-ynyl]-3,5,5-trimethylcyclohex-3-en-1-ol

(R)-4-((1E,3E)-4-iodo-3-methylbuta-1,3-dien-1-yl)-3,5,5-trimethylcyclohex-3-en-1-ol