methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate

Base Information

• Chemical Name: methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate
• CAS No.: 903528-00-7
• Molecular Formula: C₁₄H₁₇NO₄
• Molecular Weight: 263.293
• Mol file: 903528-00-7.mol

Synonyms:methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate

Chemical Property of methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate

There total 3 articles about methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

Benzyloxymethyl chloride (3587-60-8) + methyl 5-oxopyrrolidine-2-carboxylate (4931-66-2,54571-66-3,64700-65-8) → methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate (903528-00-7)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2006.04.070

Reference yield: 27.0%

Benzyloxymethyl chloride (3587-60-8) + methyl (2R)-pyroglutamate (64700-65-8) → methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate (903528-00-7)

Guidance literature:

methyl (2R)-pyroglutamate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -30 ℃; for 1h;

Benzyloxymethyl chloride; In tetrahydrofuran; at -78 - -30 ℃; for 1h;

Reference yield:

methyl (+/-)-2-hydroxymethyl-5-oxopyrrolidine-2-carboxylate (872832-89-8) + 2-benzyloxy-1-methylpyridinium triflate (882980-43-0) → methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate (903528-00-7)

Guidance literature:

With magnesium oxide; In various solvent(s); Heating;

DOI:10.1016/j.tetlet.2006.11.087

upstream raw materials:

Benzyloxymethyl chloride

methyl 5-oxopyrrolidine-2-carboxylate

methyl (+/-)-2-hydroxymethyl-5-oxopyrrolidine-2-carboxylate

2-benzyloxy-1-methylpyridinium triflate

Downstream raw materials:

1-tert-butyl 2-methyl 2-[(benzyloxy)methyl]-5-oxo-1H-pyrrole-1,2-(2H,5H)-dicarboxylate

1-tert-butyl 2-methyl 2-[(benzyloxy)methyl]-5-oxo-pyrrolidine-1,2-dicarboxylate