882980-43-0

Basic information

• Product Name: Bn-OPT, Dudley Reagent
• Synonyms: 2-Benzyloxy-1-methylpyridinium triflate;Bn-OPT, Dudley Reagent;2-Benzyloxy-1-methylpyridinium Trifluoromethanesulfonate;1-Methyl-2-(phenylmethoxy)-pyridinium 1,1,1-trifluoromethanesulfonate;Dudley's reagent;Bn-OPT;2-Benzyloxy-1-methylpyridinium Trifluoromethanesulfonate (This product is only available in Japan.);2-Benzyloxy-1-methylpyridinium triflate 96%
• CAS NO: 882980-43-0
• Molecular Formula: C14H14F3NO4S
• Molecular Weight: 0
• Mol File: 882980-43-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 85-91 °C
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Bn-OPT, Dudley Reagent(CAS DataBase Reference)
• NIST Chemistry Reference: Bn-OPT, Dudley Reagent(882980-43-0)
• EPA Substance Registry System: Bn-OPT, Dudley Reagent(882980-43-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 882980-43-0(Hazardous Substances Data)

Usage

Uses

Dudley ReagentsNovel reagent for benzyl protection of alcohols under neutral conditions. Promotes selective formation of benzyl esters of carboxylic acids in presence of triethylamine.

InChI:InChI=1/C13H14NO.CHF3O3S/c1-14-10-6-5-9-13(14)15-11-12-7-3-2-4-8-12;2-1(3,4)8(5,6)7/h2-10H,11H2,1H3;(H,5,6,7)/q+1;/p-1

Upstream product

• 100-51-6 benzyl alcohol 
• 109-09-1 2-chloropyridine 
• 40864-08-2 2-benzyloxypyridine 
• 333-27-7 methyl trifluoromethanesulfonate 

Downstream Products

• 32565-76-7 (2,6-dimethyloxy-4-methyl)phenyl 
• 32565-33-6 1-benzyl-2,4-dimethoxybenzene 
• 2116-36-1 1-benzyl-4-bromo-benzene 
• 23450-18-2 2-benzyl-1-bromobenzene 
• 1417721-70-0 C₆₈H₇₄N₆O₁₃ 
• 1394226-64-2 5-((2S,4S)-2-(benzyloxy)-4-hydroxyhept-6-en-1-yl)-7-methoxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one 

Relevant articles and documents

3BéTA-(BENZYLOXY)-17ALPHA-METHYL-PREGN-5-EN-20-ONE FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS

The present invention generally relates to a specific pregnenolone derivative for its use for the treatment of a cognitive disorders. More particularly, the invention relates to a compound of Formula (I) for its use in the treatment of cognitive disorders. Indeed, the compound of the invention is in vivo very potent in correcting the cognitive impairments observed in cognitive disorders.

Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis

A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.

Mix-and-heat benzylation of alcohols using a bench-stable pyridinium salt

2-Benzyloxy-1-methylpyridinium inflate (1) is a stable, neutral organic salt that converts alcohols into benzyl ethers upon warming. The synthesis and reactivity of 1 are described herein. Benzylation of a wide range of alcohols occurs in good to excellent yield.