(1'R,2'R,3'S)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-thymine

Base Information

Chemical Name:(1'R,2'R,3'S)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-thymine
CAS No.:283598-22-1
Molecular Formula:C₃₂H₃₄N₂O₆
Molecular Weight:542.632
Hs Code.:

Synonyms:(1'R,2'R,3'S)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-thymine

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Chemical Property of (1'R,2'R,3'S)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-thymine

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Technology Process of (1'R,2'R,3'S)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-thymine

There total 10 articles about (1'R,2'R,3'S)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 285138-30-9
(1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]thymine

: 283598-22-1
(1'R,2'R,3'S)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-thymine

Guidance literature:: 4,4'-dimethoxytrityl chloride; (1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]thymine; With pyridine; at 20 ℃; for 48h;

With sodium hydroxide; In 1,4-dioxane; methanol; water; at 20 ℃; for 12h;
DOI:10.1016/S0040-4020(00)00162-9

Reference yield:

: 132294-18-9
<1S-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

: 283598-22-1
(1'R,2'R,3'S)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-thymine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / LiN₃ / dimethylformamide / 15 h / 100 °C

2.1: 96 percent / H₂ / Pd/C / ethanol / 10 h / 20 °C

3.1: toluene / 1 h / 80 °C

3.2: 99 percent / toluene / 4 h / 20 °C

4.1: 72 percent / H₂SO₄ / dioxane; H₂O / 1.67 h / 100 °C

5.1: 70 percent / lipase MY / acetone; aq. phosphate buffer / 504 h / 36 °C / pH 7.0 / Enzymatic reaction

6.1: Py / 48 h / 20 °C

6.2: 75 percent / NaOH / dioxane; H₂O; methanol / 12 h / 20 °C

With pyridine; lithium azide; Lipase MY; sulfuric acid; hydrogen; palladium on activated charcoal; In 1,4-dioxane; phosphate buffer; ethanol; water; N,N-dimethyl-formamide; acetone; toluene; 1.1: Substitution / 2.1: Catalytic hydrogenation / 3.1: Substitution / 3.2: Substitution / 4.1: Cyclization / 5.1: Hydrolysis / 6.1: Substitution / 6.2: Hydrolysis;
DOI:10.1016/S0040-4020(00)00162-9