N-(6-{6-chloro-5-[fluoro(phenylsulfonyl)methyl]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide

Base Information

Chemical Name:N-(6-{6-chloro-5-[fluoro(phenylsulfonyl)methyl]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide
CAS No.:1309778-66-2
Molecular Formula:C₂₄H₁₇ClFN₅O₃S₂
Molecular Weight:542.014
Hs Code.:

Synonyms:N-(6-{6-chloro-5-[fluoro(phenylsulfonyl)methyl]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide

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Chemical Property of N-(6-{6-chloro-5-[fluoro(phenylsulfonyl)methyl]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide

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Technology Process of N-(6-{6-chloro-5-[fluoro(phenylsulfonyl)methyl]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide

There total 11 articles about N-(6-{6-chloro-5-[fluoro(phenylsulfonyl)methyl]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198437-65-8
2-methyl-N-[2-(tetrahydro-2H-pyran-2-yl)-6-(4,4,6,6-tetramethyl-1,3,2-dioxaborinan-2-yl)-2H-indazol-4-yl]-1,3-thiazole-4-carboxamide

: 1309778-77-5
5-bromo-2-chloro-3-[fluoro(phenylsulfonyl)methyl]pyridine

: 1309778-66-2
N-(6-{6-chloro-5-[fluoro(phenylsulfonyl)methyl]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 140 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 873-55-2
sodium benzenesulfonate

: 1309778-66-2
N-(6-{6-chloro-5-[fluoro(phenylsulfonyl)methyl]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 20 °C

2: sodium hexamethyldisilazane / 2-methyltetrahydrofuran / -78 °C

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 140 °C / Microwave irradiation

With sodium hexamethyldisilazane; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 2-methyltetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 55842-53-0
2-methyl-4-thiazolecarbonyl chloride

: 1309778-66-2
N-(6-{6-chloro-5-[fluoro(phenylsulfonyl)methyl]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 1 h / 20 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.5 h / 80 °C / Microwave irradiation

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 140 °C / Microwave irradiation

With pyridine; potassium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water;