4-Thiazolecarbonyl chloride, 2-methyl- (9CI)

Base Information

• Chemical Name: 4-Thiazolecarbonyl chloride, 2-methyl- (9CI)
• CAS No.: 55842-53-0
• Molecular Formula: C5H4ClNOS
• Molecular Weight: 161.612
• Hs Code.: 2934100090
• Mol file: 55842-53-0.mol

Synonyms:4-Thiazolecarbonyl chloride, 2-methyl- (9CI);2-Methyl-4-thiazolecarbonyl chloride

Chemical Property of 4-Thiazolecarbonyl chloride, 2-methyl- (9CI)

Chemical Property:

• Vapor Pressure: 0.0738mmHg at 25°C
• Refractive Index: 1.572
• Boiling Point: 228.3°Cat760mmHg
• Flash Point: 91.9°C
• PSA: 58.20000
• Density: 1.407g/cm³
• LogP: 1.83050

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-1,3-thiazole-4-carbonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Thiazolecarbonyl chloride, 2-methyl- (9CI)

There total 1 articles about 4-Thiazolecarbonyl chloride, 2-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylthiazole-4-carboxylic acid (35272-15-2) → 2-methyl-4-thiazolecarbonyl chloride (55842-53-0)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In toluene; at 105 ℃; for 1.33333h;

DOI:10.1021/jm050570f

Reference yield: 94.0%

1-((4-phenyl)sulfonyl)-6-(trimethylstannyl)-1H-indazol-4-amine (1198437-73-8) + 2-methyl-4-thiazolecarbonyl chloride (55842-53-0) → 2-methyl-N-[1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide (1198437-75-0)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.5b00767

Reference yield: 93.0%

2-methyl-4-thiazolecarbonyl chloride (55842-53-0) + phenethylamine (64-04-0) → 2-methyl-N-phenethylthiazole-4-carboxamide

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1021/acs.jmedchem.9b01313

upstream raw materials:

2-methylthiazole-4-carboxylic acid

Downstream raw materials:

2-methyl-N-[1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide

C₁₈H₂₁ClN₄OS

2-bromo-1-(2'-methylthiazol-4'-yl)ethanone

2-methyl-N-(1-methyl-6-{1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide