3-[4-[6-(4-Acetyl-phenyl)-hexyloxy]-3-(2-carboxy-ethyl)-benzoyl]-benzoic acid

Base Information

Chemical Name:3-[4-[6-(4-Acetyl-phenyl)-hexyloxy]-3-(2-carboxy-ethyl)-benzoyl]-benzoic acid
CAS No.:128578-13-2
Molecular Formula:C₃₁H₃₂O₇
Molecular Weight:516.591
Hs Code.:

Synonyms:3-[4-[6-(4-Acetyl-phenyl)-hexyloxy]-3-(2-carboxy-ethyl)-benzoyl]-benzoic acid

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Chemical Property of 3-[4-[6-(4-Acetyl-phenyl)-hexyloxy]-3-(2-carboxy-ethyl)-benzoyl]-benzoic acid

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Technology Process of 3-[4-[6-(4-Acetyl-phenyl)-hexyloxy]-3-(2-carboxy-ethyl)-benzoyl]-benzoic acid

There total 13 articles about 3-[4-[6-(4-Acetyl-phenyl)-hexyloxy]-3-(2-carboxy-ethyl)-benzoyl]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 128577-90-2
2-{[6-(4-Acetylphenyl)hexyl]oxy}-5-[3(ethoxycarbonyl)benzoyl]benzenepropanoic acid ethyl ester

: 128578-13-2
3-[4-[6-(4-Acetyl-phenyl)-hexyloxy]-3-(2-carboxy-ethyl)-benzoyl]-benzoic acid

Guidance literature:: With potassium hydroxide; In ethanol; at 25 ℃; for 1h;
DOI:10.1021/jm00172a020

Reference yield:

: 16424-56-9
trans 6-phenyl-5-hexenoic acid

: 128578-13-2
3-[4-[6-(4-Acetyl-phenyl)-hexyloxy]-3-(2-carboxy-ethyl)-benzoyl]-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / H₂ / 5percent Pd/C / ethyl acetate / 1 h / 25 °C / 1551.4 Torr

2: 91 percent / LiAlH₄ / diethyl ether / 4 h / 25 °C

3: 43 percent / AlCl₃ / CH₂Cl₂ / 25 °C

4: triethylamine (TEA) / diethyl ether

5: 1.) 60percent sodium hydride disp. in oil / 1.) DMF, 25 deg C, 30 min, 2.) 65 deg C

6: 66 percent / KOH / aq. ethanol / 1 h / 25 °C

With potassium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00172a020

Reference yield:

: 17814-85-6
(4-carboxybutyl)triphenylphosphonium bromide

: 128578-13-2
3-[4-[6-(4-Acetyl-phenyl)-hexyloxy]-3-(2-carboxy-ethyl)-benzoyl]-benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) lithium hexamethyldisilazide / 1.) THF, hexane, 25 deg C, 1 h, 2.) 25 deg C, 2 h

2: 95 percent / H₂ / 5percent Pd/C / ethyl acetate / 1 h / 25 °C / 1551.4 Torr

3: 91 percent / LiAlH₄ / diethyl ether / 4 h / 25 °C

4: 43 percent / AlCl₃ / CH₂Cl₂ / 25 °C

5: triethylamine (TEA) / diethyl ether

6: 1.) 60percent sodium hydride disp. in oil / 1.) DMF, 25 deg C, 30 min, 2.) 65 deg C

7: 66 percent / KOH / aq. ethanol / 1 h / 25 °C

With potassium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; hydrogen; sodium hydride; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00172a020