(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-p-tolyl-phosphinic acid ethyl ester

Base Information

Chemical Name:(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-p-tolyl-phosphinic acid ethyl ester
CAS No.:362477-27-8
Molecular Formula:C₂₆H₂₉N₂O₄P
Molecular Weight:464.501
Hs Code.:

(3-benzyloxycarbamoyl-3,4-dihydro-1<i>H</i>-isoquinolin-2-yl)-<i>p</i>-tolyl-phosphinic acid ethyl ester

Synonyms:(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-p-tolyl-phosphinic acid ethyl ester

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Chemical Property of (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-p-tolyl-phosphinic acid ethyl ester

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Technology Process of (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-p-tolyl-phosphinic acid ethyl ester

There total 5 articles about (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-p-tolyl-phosphinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 362477-56-3
ethyl 4-methylphenylphosphonochloridate

: 404001-44-1
(3R)-N-benzyloxy-1,2,3,4-tetrahydroisoquinoline-3-hydroxamide

: 362477-27-8
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-p-tolyl-phosphinic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm0103211

Reference yield:

: 622-33-3
N-benzyloxyamine

: 362477-27-8
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-p-tolyl-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / WSC; HOBt; triethylamine / dimethylformamide / 20 °C

2: 4.6 g / 4N HCl / ethyl acetate / 2 h / 20 °C

3: diisopropylethylamine / CH₂Cl₂ / 20 °C

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0103211

Reference yield:

: 106-38-7
para-bromotoluene

: 362477-27-8
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-p-tolyl-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(tripenylposphine)palladium; triethylamine / 90 °C

2: thionyl chloride; DMF / Heating

3: diisopropylethylamine / CH₂Cl₂ / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm0103211