1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylic acid

Base Information

• Chemical Name: 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylic acid
• CAS No.: 1357616-71-7
• Molecular Formula: C₂₇H₃₁N₅O₇
• Molecular Weight: 537.572
• Mol file: 1357616-71-7.mol

Synonyms:1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylic acid

Chemical Property of 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylic acid

There total 4 articles about 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate (1357616-66-0) → 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylic acid (1357616-71-7)

Guidance literature:

methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate; With sodium hydroxide; In methanol; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In diethyl ether; water; pH=4;

DOI:10.1016/j.ejmech.2011.12.031

Reference yield:

N-(tert-butoxycarbonyl)-1,4-phenylenediamine (71026-66-9) → 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylic acid (1357616-71-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / methanol; water

2.1: silver carbonate / 1,4-dioxane / 24 h / 80 °C

3.1: sodium hydroxide / methanol / 20 °C / Inert atmosphere

3.2: pH 4

With hydrogenchloride; silver carbonate; sodium hydroxide; sodium nitrite; In 1,4-dioxane; methanol; water;

DOI:10.1016/j.ejmech.2011.12.031

Reference yield:

(Z)-methyl 2-(2-(4-((tert-butoxycarbonyl)amino)phenyl)hydrazono)-2-chloroacetate → 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylic acid (1357616-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: silver carbonate / 1,4-dioxane / 24 h / 80 °C

2.1: sodium hydroxide / methanol / 20 °C / Inert atmosphere

2.2: pH 4

With silver carbonate; sodium hydroxide; In 1,4-dioxane; methanol;

DOI:10.1016/j.ejmech.2011.12.031

upstream raw materials:

tert-butyl (4-propiolamidophenyl)carbamate

methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate

N-(tert-butoxycarbonyl)-1,4-phenylenediamine

Downstream raw materials:

C₃₅H₄₀N₆O₆

N₅,1-bis(4-aminophenyl)-N₃-(2,3-dimethylphenyl)-1H-pyrazole-3,5-dicarboxamide