methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate

Base Information

• Chemical Name: methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate
• CAS No.: 1357616-66-0
• Molecular Formula: C₂₈H₃₃N₅O₇
• Molecular Weight: 551.599
• Mol file: 1357616-66-0.mol

Synonyms:methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate

Chemical Property of methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate

There total 2 articles about methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

tert-butyl (4-propiolamidophenyl)carbamate (1357616-61-5) + (Z)-methyl 2-(2-(4-((tert-butoxycarbonyl)amino)phenyl)hydrazono)-2-chloroacetate → methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate (1357616-66-0) + methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-4-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate (1357616-70-6)

Guidance literature:

With silver carbonate; In 1,4-dioxane; at 80 ℃; for 24h;

DOI:10.1016/j.ejmech.2011.12.031

Reference yield:

N-(tert-butoxycarbonyl)-1,4-phenylenediamine (71026-66-9) → methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate (1357616-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; sodium nitrite / methanol; water

2: silver carbonate / 1,4-dioxane / 24 h / 80 °C

With hydrogenchloride; silver carbonate; sodium nitrite; In 1,4-dioxane; methanol; water;

DOI:10.1016/j.ejmech.2011.12.031

Reference yield: 40.0%

methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate (1357616-66-0) → 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylic acid (1357616-71-7)

Guidance literature:

methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate; With sodium hydroxide; In methanol; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In diethyl ether; water; pH=4;

DOI:10.1016/j.ejmech.2011.12.031

upstream raw materials:

tert-butyl (4-propiolamidophenyl)carbamate

N-(tert-butoxycarbonyl)-1,4-phenylenediamine

Downstream raw materials:

1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylic acid

C₃₅H₄₀N₆O₆

N₅,1-bis(4-aminophenyl)-N₃-(2,3-dimethylphenyl)-1H-pyrazole-3,5-dicarboxamide