5-(aminomethyl)-6-chloro-N-(2,6-difluorophenyl)-2-(methylthio)-4-pyrimidinamine

Base Information

Chemical Name:5-(aminomethyl)-6-chloro-N-(2,6-difluorophenyl)-2-(methylthio)-4-pyrimidinamine
CAS No.:911370-60-0
Molecular Formula:C₁₂H₁₁ClF₂N₄S
Molecular Weight:316.762
Hs Code.:

Synonyms:5-(aminomethyl)-6-chloro-N-(2,6-difluorophenyl)-2-(methylthio)-4-pyrimidinamine

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Chemical Property of 5-(aminomethyl)-6-chloro-N-(2,6-difluorophenyl)-2-(methylthio)-4-pyrimidinamine

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Technology Process of 5-(aminomethyl)-6-chloro-N-(2,6-difluorophenyl)-2-(methylthio)-4-pyrimidinamine

There total 7 articles about 5-(aminomethyl)-6-chloro-N-(2,6-difluorophenyl)-2-(methylthio)-4-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 357935-93-4
4-Chloro-6-(2,6-difluoro-phenylamino)-2-methylsulfanyl-pyrimidine-5-carbonitrile

: 911370-60-0
5-(aminomethyl)-6-chloro-N-(2,6-difluorophenyl)-2-(methylthio)-4-pyrimidinamine

Guidance literature:: 4-Chloro-6-(2,6-difluoro-phenylamino)-2-methylsulfanyl-pyrimidine-5-carbonitrile; With borane-THF; for 4h; Heating / reflux;

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 0.5h;

With sodium hydroxide; In tetrahydrofuran; water; pH=9.0 - 10.0;

Reference yield:

: 33097-11-9
4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxyaldehyde

: 911370-60-0
5-(aminomethyl)-6-chloro-N-(2,6-difluorophenyl)-2-(methylthio)-4-pyrimidinamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; acetic acid / ethanol / 2 h / 20 - 70 °C

2.1: thionyl chloride / 3 h / 20 - 75 °C

3.1: N,N-dimethyl-formamide / 1 h / 50 °C

4.1: borane-THF / tetrahydrofuran / 4 h / Heating / reflux

4.2: 0.5 h / 20 °C

4.3: pH 9.0 - 10.0

With thionyl chloride; borane-THF; hydroxylamine hydrochloride; acetic acid; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1979-98-2
2,4-dihydroxy-2-methylmercaptopyrimidine (zwitterionic form)

: 911370-60-0
5-(aminomethyl)-6-chloro-N-(2,6-difluorophenyl)-2-(methylthio)-4-pyrimidinamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / Trichloroethylene / 5 - 20 °C

1.2: 80 °C

2.1: hydroxylamine hydrochloride; acetic acid / ethanol / 2 h / 20 - 70 °C

3.1: thionyl chloride / 3 h / 20 - 75 °C

4.1: N,N-dimethyl-formamide / 1 h / 50 °C

5.1: borane-THF / tetrahydrofuran / 4 h / Heating / reflux

5.2: 0.5 h / 20 °C

5.3: pH 9.0 - 10.0

With thionyl chloride; borane-THF; hydroxylamine hydrochloride; acetic acid; trichlorophosphate; In tetrahydrofuran; ethanol; Trichloroethylene; N,N-dimethyl-formamide;