2-chloro-4-((3S,3aS)-5-hydroxy-3-methoxy-5-(trifluoromethyl)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile

Base Information

• Chemical Name: 2-chloro-4-((3S,3aS)-5-hydroxy-3-methoxy-5-(trifluoromethyl)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile
• CAS No.: 1421375-36-1
• Molecular Formula: C₁₆H₁₅ClF₃N₃O₂
• Molecular Weight: 373.762
• Mol file: 1421375-36-1.mol

Synonyms:2-chloro-4-((3S,3aS)-5-hydroxy-3-methoxy-5-(trifluoromethyl)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile

Chemical Property of 2-chloro-4-((3S,3aS)-5-hydroxy-3-methoxy-5-(trifluoromethyl)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-4-((3S,3aS)-5-hydroxy-3-methoxy-5-(trifluoromethyl)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile

There total 2 articles about 2-chloro-4-((3S,3aS)-5-hydroxy-3-methoxy-5-(trifluoromethyl)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

2-chloro-4-((3S,3aS)-3-methoxy-5-oxo-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile (1421375-34-9) + (trifluoromethyl)trimethylsilane (81290-20-2) → 2-chloro-4-((3S,3aS)-5-hydroxy-3-methoxy-5-(trifluoromethyl)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile (1421375-36-1)

Guidance literature:

2-chloro-4-((3S,3aS)-3-methoxy-5-oxo-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile; (trifluoromethyl)trimethylsilane; With cesium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield:

2-chloro-4-((3S,3aS,5R)-5-hydroxy-3-methoxy-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile (1421375-33-8) → 2-chloro-4-((3S,3aS)-5-hydroxy-3-methoxy-5-(trifluoromethyl)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile (1421375-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 24 h / 20 °C

2: cesium fluoride / tetrahydrofuran / 3 h / 0 - 20 °C

With Dess-Martin periodane; cesium fluoride; In tetrahydrofuran; dichloromethane;

upstream raw materials:

2-chloro-4-((3S,3aS,5R)-5-hydroxy-3-methoxy-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile

2-chloro-4-((3S,3aS)-3-methoxy-5-oxo-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile

(trifluoromethyl)trimethylsilane