methyl 2-(6-(4-tert-butylphenylsulfonamido)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yloxy)acetate

Base Information

Chemical Name:methyl 2-(6-(4-tert-butylphenylsulfonamido)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yloxy)acetate
CAS No.:180576-46-9
Molecular Formula:C₂₈H₂₉N₅O₇S
Molecular Weight:579.634
Hs Code.:

Synonyms:methyl 2-(6-(4-tert-butylphenylsulfonamido)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yloxy)acetate

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Chemical Property of methyl 2-(6-(4-tert-butylphenylsulfonamido)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yloxy)acetate

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Technology Process of methyl 2-(6-(4-tert-butylphenylsulfonamido)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yloxy)acetate

There total 2 articles about methyl 2-(6-(4-tert-butylphenylsulfonamido)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 174227-14-6
p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide

: 96-34-4
methyl chloroacetate

: 180576-46-9
methyl 2-(6-(4-tert-butylphenylsulfonamido)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yloxy)acetate

Guidance literature:: p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide; With sodium carbonate; In N,N-dimethyl-formamide; at 110 - 115 ℃;

methyl chloroacetate; In N,N-dimethyl-formamide; at 80 - 85 ℃; for 4h;
DOI:10.2174/1570178611310050011

Reference yield:

: 150727-06-3
4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide

: 180576-46-9
methyl 2-(6-(4-tert-butylphenylsulfonamido)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yloxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / toluene; dimethyl sulfoxide; water / 13 h / 110 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 110 - 115 °C

2.2: 4 h / 80 - 85 °C

With sodium carbonate; sodium hydroxide; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.2174/1570178611310050011