BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)-

Base Information

Chemical Name:BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)-
CAS No.:174227-14-6
Molecular Formula:C25H25N5O5S
Molecular Weight:507.57
Hs Code.:2935909550
Mol file:174227-14-6.mol

Synonyms:BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)-;Bosentan USP RC B;Bosentan IMpurity D;Bosentan Related CoMpound B;N-[1,6-Dihydro-5-(2-methoxyphenoxy)-6-oxo[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide;Bosentan Related Compound B (15 mg) (4-(tert-butyl)-N-[6-hydroxy-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl]benzenesulfonamide);O-Deshydroxyethyl Bosentan;Bosentan USP Related Compound B: 4-(tert-Butyl)-N-[6-hydroxy-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl]benzenesulfonamide

Suppliers and Price of BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
O-DeshydroxyethylBosentan
500mg
$ 1390.00

ChemScene
Benzenesulfonamide,N-[1,6-dihydro-5-(2-methoxyphenoxy)-6-oxo[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-
1g
$ 350.00

Chemenu
4-(tert-butyl)-N-(6-hydroxy-5-(2-methoxyphenoxy)-[2,2''-bipyrimidin]-4-yl)benzenesulfonamide 95%+
1g
$ 637.00

Chemenu
4-(tert-butyl)-N-(6-hydroxy-5-(2-methoxyphenoxy)-[2,2''-bipyrimidin]-4-yl)benzenesulfonamide 95%+
100mg
$ 177.00

Chemenu
4-(tert-butyl)-N-(6-hydroxy-5-(2-methoxyphenoxy)-[2,2''-bipyrimidin]-4-yl)benzenesulfonamide 95%+
250mg
$ 273.00

Biosynth Carbosynth
O-Deshydroxyethyl bosentan
5 mg
$ 400.00

Biosynth Carbosynth
O-Deshydroxyethyl bosentan
2 mg
$ 200.00

Biosynth Carbosynth
O-Deshydroxyethyl bosentan
1 mg
$ 120.00

Biosynth Carbosynth
O-Deshydroxyethyl bosentan
25 mg
$ 950.00

Biosynth Carbosynth
O-Deshydroxyethyl bosentan
10 mg
$ 650.00

Total 12 raw suppliers

Chemical Property of BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)-

Chemical Property:

PSA：144.80000
LogP:5.69220
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

O-DeshydroxyethylBosentan ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses O-Deshydroxyethyl Bosentan (Bosentan USP Related Compound B) is an impurity of Bosentan (B675900); a mixed endothelin receptor antagonist. Used as a vasodilator and antihypertensive.

Technology Process of BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)-

There total 17 articles about BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 150727-06-3
4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide

: 174227-14-6
p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide

Guidance literature:: With sodium hydroxide; In water; dimethyl sulfoxide; toluene; at 110 ℃; for 13h;
DOI:10.2174/1570178611310050011

Reference yield:

: 107-21-1
ethylene glycol

: 150727-06-3
4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide

: 174227-14-6
p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide

: 147536-97-8,174227-18-0
bosentan

Guidance literature:: ethylene glycol; With sodium hydroxide; In tetrahydrofuran; at 50 ℃; for 0.5h;

4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide; In tetrahydrofuran; at 50 - 65 ℃; for 12h;