dl-trans-2-benzyloxymethyl-3-(tetrahydropyran-2-yloxy)tetrahydropyran

Base Information

Chemical Name:dl-trans-2-benzyloxymethyl-3-(tetrahydropyran-2-yloxy)tetrahydropyran
CAS No.:107757-70-0
Molecular Formula:C₁₈H₂₆O₄
Molecular Weight:306.402
Hs Code.:

Synonyms:dl-trans-2-benzyloxymethyl-3-(tetrahydropyran-2-yloxy)tetrahydropyran

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Chemical Property of dl-trans-2-benzyloxymethyl-3-(tetrahydropyran-2-yloxy)tetrahydropyran

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Technology Process of dl-trans-2-benzyloxymethyl-3-(tetrahydropyran-2-yloxy)tetrahydropyran

There total 10 articles about dl-trans-2-benzyloxymethyl-3-(tetrahydropyran-2-yloxy)tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 89429-83-4,104954-94-1,104975-67-9
dl-trans-2-benzyloxymethyltetrahydropyran-3-ol

: 107757-70-0
dl-trans-2-benzyloxymethyl-3-(tetrahydropyran-2-yloxy)tetrahydropyran

Guidance literature:: pyridinium p-toluenesulfonate; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1248/cpb.37.2379

Reference yield:

: 100-44-7
benzyl chloride

: 107757-70-0
dl-trans-2-benzyloxymethyl-3-(tetrahydropyran-2-yloxy)tetrahydropyran

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / 55percent NaH / dimethylformamide / 16 h / Ambient temperature

2: 1.) 1M BH₃, 2.) 10percent aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, room temp., 3 h, 2.) THF, H₂O, room temp., 1 h

3: 96 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 4 h / Ambient temperature

With sodium hydroxide; borane; dihydrogen peroxide; sodium hydride; pyridinium p-toluenesulfonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.37.2379

Reference yield:

: 100-44-7
benzyl chloride

: 107757-70-0
(2S,3S)-2-Benzyloxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / 55percent NaH / dimethylformamide / 16 h / Ambient temperature

2: 1.) 1M BH₃, 2.) 10percent aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, room temp., 3 h, 2.) THF, H₂O, room temp., 1 h

3: 2.08 g / CrO₃ / acetone / 1 h / Ambient temperature

4: L-Selectride / tetrahydrofuran / 1.) 5 deg C, 30 min, 2.) room temp., 2 h

5: pyridinium p-toluenesulfonate / CH₂Cl₂ / Ambient temperature

With chromium(VI) oxide; sodium hydroxide; borane; dihydrogen peroxide; L-Selectride; sodium hydride; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.37.2379