methyl 4-[[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]thio]phenyl ether

Base Information

• Chemical Name: methyl 4-[[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]thio]phenyl ether
• CAS No.: 193964-32-8
• Molecular Formula: C₂₂H₁₈O₂S₂
• Molecular Weight: 378.516
• Mol file: 193964-32-8.mol

Synonyms:methyl 4-[[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]thio]phenyl ether

Chemical Property of methyl 4-[[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]thio]phenyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-[[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]thio]phenyl ether

There total 3 articles about methyl 4-[[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]thio]phenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

water (7732-18-5) + 3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene (26563-22-4) → methyl 4-[[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]thio]phenyl ether (193964-32-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; methanol; ethyl acetate;

Reference yield:

4,4'-dimethoxyphenyl disulfide (5335-87-5) + 3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene (26563-22-4) → methyl 4-[[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]thio]phenyl ether (193964-32-8)

Guidance literature:

3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

4,4'-dimethoxyphenyl disulfide; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;

DOI:10.1021/jm9903388

Reference yield:

2-(4-methoxyphenyl)benzo[b]thiophene (27884-09-9) → methyl 4-[[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]thio]phenyl ether (193964-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 94 percent / Br₂ / CHCl₃ / 1 h / 0 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.17 h / -78 °C

2.2: 0.82 g / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; bromine; In tetrahydrofuran; hexane; chloroform; 1.1: Bromination / 2.1: Metallation / 2.2: thioetheryfication;

DOI:10.1021/jm9903388

upstream raw materials:

4,4'-dimethoxyphenyl disulfide

3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene

2-(4-methoxyphenyl)benzo[b]thiophene

water

Downstream raw materials:

4-[[2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl]thio]phenol