3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene

Base Information

• Chemical Name: 3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene
• CAS No.: 26563-22-4
• Molecular Formula: C₁₅H₁₁BrOS
• Molecular Weight: 319.222
• Mol file: 26563-22-4.mol

Synonyms:3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene

Chemical Property of 3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene

There total 10 articles about 3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-((4-methoxyphenyl)ethynyl)-2-(methylsulfanyl)benzene (84904-70-1) → 3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene (26563-22-4)

Guidance literature:

With bis(N-methyl-2-pyrrolidinone)hydrogen tribromide; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/ejoc.201000529

Reference yield: 94.0%

2-(4-methoxyphenyl)benzo[b]thiophene (27884-09-9) → 3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene (26563-22-4)

Guidance literature:

With bromine; In chloroform; at 0 ℃; for 1h;

DOI:10.1021/jm9903388

Reference yield: 88.0%

3-Bromothianaphthene (7342-82-7) + para-iodoanisole (696-62-8) → 3-bromo-2-(4-methoxyphenyl)benzo[b]thiophene (26563-22-4)

Guidance literature:

3-Bromothianaphthene; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.666667h; Inert atmosphere;

With zinc dibromide; In tetrahydrofuran; at 0 - 20 ℃; for 0.666667h; Inert atmosphere;

para-iodoanisole; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 50 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.10.158

upstream raw materials:

2-(4-methoxyphenyl)benzo[b]thiophene

1-((4-methoxyphenyl)ethynyl)-2-(methylsulfanyl)benzene

2-(methylthio)iodobenzene

4-methoxyphenylacetylen

Downstream raw materials:

methyl 4-[[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]thio]phenyl ether

4-[[2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl]thio]phenol

3,4,5-trimethoxy styrene