ethyl 4-(4-chlorophenyl)-2-(dimethylaminomethyleneamino)thiophene-3-carboxylate

Base Information

• Chemical Name: ethyl 4-(4-chlorophenyl)-2-(dimethylaminomethyleneamino)thiophene-3-carboxylate
• CAS No.: 327084-90-2
• Molecular Formula: C₁₆H₁₇ClN₂O₂S
• Molecular Weight: 336.842

Synonyms:ethyl 4-(4-chlorophenyl)-2-(dimethylaminomethyleneamino)thiophene-3-carboxylate

Chemical Property of ethyl 4-(4-chlorophenyl)-2-(dimethylaminomethyleneamino)thiophene-3-carboxylate

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Technology Process of ethyl 4-(4-chlorophenyl)-2-(dimethylaminomethyleneamino)thiophene-3-carboxylate

There total 1 articles about ethyl 4-(4-chlorophenyl)-2-(dimethylaminomethyleneamino)thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 2-amino-4-chlorophenyl-thiophene-3-carboxylate (65234-09-5) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → ethyl 4-(4-chlorophenyl)-2-(dimethylaminomethyleneamino)thiophene-3-carboxylate (327084-90-2)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 7h; Reflux;

DOI:10.1515/hc-2012-0095

Reference yield: 61.0%

ethyl 4-(4-chlorophenyl)-2-(dimethylaminomethyleneamino)thiophene-3-carboxylate (327084-90-2) + 4-Methoxyphenethylamine (55-81-2) → 5-(4-chlorophenyl)-3-(4-methoxyphenethyl)thieno[2,3-d]pyrimidin-4(3H)-one (898643-21-5)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 30h; Reflux;

DOI:10.1515/hc-2012-0095

Reference yield: 57.1%

ethyl 4-(4-chlorophenyl)-2-(dimethylaminomethyleneamino)thiophene-3-carboxylate (327084-90-2) + phenethylamine (64-04-0) → 5-chlorophenyl-3-phenethylthieno[2,3-d]pyrimidine-4(3H)-one (449152-29-8)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 35h; Reflux;

DOI:10.1016/j.bmcl.2014.01.072

upstream raw materials:

ethyl 2-amino-4-chlorophenyl-thiophene-3-carboxylate

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

(Z)-ethyl 2-(3-tert-butoxy-2-cyano-3-oxoprop-1-enylamino)-4-(4-chlorophenyl)thiophene-3-carboxylate

5-(4-chlorophenyl)-3-(4-methoxyphenethyl)thieno[2,3-d]pyrimidin-4(3H)-one

5-(4-chlorophenyl)-3-[(3-pyridyl)methyl]thieno[2,3-d]pyrimidin-4(3H)-one

5-chlorophenyl-3-phenethylthieno[2,3-d]pyrimidine-4(3H)-one

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