(S)-((S,Z)-3-((2R,3S)-3-Carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl2-(tert-butoxycarbonylamino)propanoate

Base Information

• Chemical Name: (S)-((S,Z)-3-((2R,3S)-3-Carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl2-(tert-butoxycarbonylamino)propanoate
• CAS No.: 1581704-61-1
• Molecular Formula: C₃₄H₃₉F₆N₅O₇
• Molecular Weight: 743.703
• Mol file: 1581704-61-1.mol

Synonyms:(S)-((S,Z)-3-((2R,3S)-3-Carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl2-(tert-butoxycarbonylamino)propanoate

Chemical Property of (S)-((S,Z)-3-((2R,3S)-3-Carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl2-(tert-butoxycarbonylamino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-((S,Z)-3-((2R,3S)-3-Carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl2-(tert-butoxycarbonylamino)propanoate

There total 2 articles about (S)-((S,Z)-3-((2R,3S)-3-Carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl2-(tert-butoxycarbonylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.8%

(2R,3S)-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide (1401066-80-5) + N-[(1,1-dimethylethoxy)carbonyl]-L-alanine chloromethyl ester (150109-42-5) → (S)-((S,Z)-3-((2R,3S)-3-Carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl2-(tert-butoxycarbonylamino)propanoate (1581704-61-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

L-N-Boc-Ala (15761-38-3) → (S)-((S,Z)-3-((2R,3S)-3-Carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl2-(tert-butoxycarbonylamino)propanoate (1581704-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; tetra(n-butyl)ammonium hydrogensulfate / water; dichloromethane / 0.57 h / 20 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield: 36.3%

(S)-((S,Z)-3-((2R,3S)-3-Carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl2-(tert-butoxycarbonylamino)propanoate (1581704-61-1) → ((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl L-alaninate (1581704-36-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 4h;

upstream raw materials:

(2R,3S)-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

N-[(1,1-dimethylethoxy)carbonyl]-L-alanine chloromethyl ester

L-N-Boc-Ala

Downstream raw materials:

((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl L-alaninate