150109-42-5

Basic information

• Product Name: L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, chloromethyl ester
• CAS NO: 150109-42-5
• Molecular Formula: C9H16ClNO4
• Molecular Weight: 237.683
• Mol File: 150109-42-5.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, chloromethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, chloromethyl ester(150109-42-5)
• EPA Substance Registry System: L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, chloromethyl ester(150109-42-5)

Safety Data

• Hazardous Substances Data: 150109-42-5(Hazardous Substances Data)

Upstream product

• 49715-04-0 chlorosulfuric acid chloromethyl ester 
• 15761-38-3 L-N-Boc-Ala 
• 74-97-5 chlorobromomethane 
• 42538-65-8 N-(tert-butoxycarbonyl)-(S)-alanine cesium salt 

Downstream Products

• 1581704-61-1 (S)-((S,Z)-3-((2R,3S)-3-Carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl2-(tert-butoxycarbonylamino)propanoate 
• 1133711-12-2 L-2-tert-butoxycarbonylamino-propionic acid 3-[2,6-dichloro-4-(6-cyano-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-phenoxy]-5-isopropyl-6-oxo-6H-pyridazin-1-ylmethyl ester 

Relevant articles and documents

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Peptide chloromethyl esters are important compounds in prodrug synthesis. A simple, mild and efficient method for the synthesis of chloromethyl esters of N-blocked amino acids and dipeptides using exclusively bromochloromethane is reported. These N-blocke

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Disclosed are compounds of Formula (I) and/or salts thereof: wherein R1 is —CH2CH2CF3; R2 is —CH2CH2CF3 or —CH2CH2CH2CF3; R3 is H, —CH3, or Rx; R4 is H or Ry; Ring A is phenyl or pyridinyl; and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer; or as prodrugs of such compounds.