7-Oxo-4,4-diphenyl-octahydro-2-aza-4-sila-indene-2-carboxylic acid vinyl ester

Base Information

• Chemical Name: 7-Oxo-4,4-diphenyl-octahydro-2-aza-4-sila-indene-2-carboxylic acid vinyl ester
• CAS No.: 203570-62-1
• Molecular Formula: C₂₂H₂₃NO₃Si
• Molecular Weight: 377.515
• Mol file: 203570-62-1.mol

Synonyms:7-Oxo-4,4-diphenyl-octahydro-2-aza-4-sila-indene-2-carboxylic acid vinyl ester

Chemical Property of 7-Oxo-4,4-diphenyl-octahydro-2-aza-4-sila-indene-2-carboxylic acid vinyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Oxo-4,4-diphenyl-octahydro-2-aza-4-sila-indene-2-carboxylic acid vinyl ester

There total 7 articles about 7-Oxo-4,4-diphenyl-octahydro-2-aza-4-sila-indene-2-carboxylic acid vinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Vinyl chloroformate (5130-24-5) + 2-Benzyl-4,4-diphenyl-octahydro-2-aza-4-sila-inden-7-one (203570-57-4) → 7-Oxo-4,4-diphenyl-octahydro-2-aza-4-sila-indene-2-carboxylic acid vinyl ester (203570-62-1)

Guidance literature:

With triethylamine; In 1,2-dichloro-ethane; for 2.5h; Ambient temperature;

DOI:10.1055/s-1998-1588

Reference yield:

1,1-diphenyl-1-silacyclohexan-4-one (34564-75-5) → 7-Oxo-4,4-diphenyl-octahydro-2-aza-4-sila-indene-2-carboxylic acid vinyl ester (203570-62-1)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / diethyl ether / 12 h / Ambient temperature

2: CH₂Cl₂ / 12 h / Ambient temperature

3: 2.5 percent / TFA / Ambient temperature

4: 100 percent / Et₃N / 1,2-dichloro-ethane / 2.5 h / Ambient temperature

With sodium hydride; triethylamine; trifluoroacetic acid; In diethyl ether; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1055/s-1998-1588

Reference yield:

4-Oxo-1,1-diphenyl-1,4,5,6-tetrahydro-siline-3-carboxylic acid benzyl ester (203570-60-9) → 7-Oxo-4,4-diphenyl-octahydro-2-aza-4-sila-indene-2-carboxylic acid vinyl ester (203570-62-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / TFA / CH₂Cl₂ / 1 h / Ambient temperature

2: 69 percent / H₂; conc. HCl / Pd/C / methanol / 1 h / 40 °C / 1137.7 Torr

3: 100 percent / Et₃N / 1,2-dichloro-ethane / 2.5 h / Ambient temperature

With hydrogenchloride; hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1055/s-1998-1588

upstream raw materials:

Vinyl chloroformate

2-Benzyl-4,4-diphenyl-octahydro-2-aza-4-sila-inden-7-one

1,1-diphenyl-1-silacyclohexan-4-one

1,1-Diphenyl-2,3-dihydro-1H-silin-4-one

Downstream raw materials:

4,4-Diphenyl-octahydro-2-aza-4-sila-inden-7-one