7-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]-1-(3-chloro-2-fluorobenzyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Base Information

Chemical Name:7-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]-1-(3-chloro-2-fluorobenzyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS No.:1616493-05-0
Molecular Formula:C₂₇H₂₁ClFN₅O₄
Molecular Weight:533.946
Hs Code.:

Synonyms:7-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]-1-(3-chloro-2-fluorobenzyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

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Chemical Property of 7-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]-1-(3-chloro-2-fluorobenzyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

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Technology Process of 7-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]-1-(3-chloro-2-fluorobenzyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

There total 5 articles about 7-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]-1-(3-chloro-2-fluorobenzyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1616492-97-7
C₂₉H₂₅ClFN₅O₄

: 1616493-05-0
7-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]-1-(3-chloro-2-fluorobenzyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: C₂₉H₂₅ClFN₅O₄; With sodium hydroxide; In 1,4-dioxane; at 120 ℃; for 0.583333h; Microwave irradiation;

With hydrogenchloride; In water; for 0.5h; pH=2;
DOI:10.1021/jm500340h

Reference yield:

: 138998-49-9
ethyl 2-[(2,6-dichloro-3-pyridinyl)carbonyl]-3-(dimethylamino)-2-propenoate

: 1616493-05-0
7-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]-1-(3-chloro-2-fluorobenzyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether; ethanol / 2 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3.1: N,N-dimethyl-formamide / 5 h / 80 °C

4.1: sodium hydroxide / 1,4-dioxane / 0.58 h / 120 °C / Microwave irradiation

4.2: 0.5 h / pH 2

With potassium carbonate; sodium hydroxide; In 1,4-dioxane; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm500340h

Reference yield:

: 1616493-23-2
ethyl 3-[(3-chloro-2-fluorobenzyl)amino]-2-[(2,6-dichloropyridin-3-yl)carbonyl]acrylate

: 1616493-05-0
7-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]-1-(3-chloro-2-fluorobenzyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

2.1: N,N-dimethyl-formamide / 5 h / 80 °C

3.1: sodium hydroxide / 1,4-dioxane / 0.58 h / 120 °C / Microwave irradiation

3.2: 0.5 h / pH 2

With potassium carbonate; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm500340h