-4-benzyl-3-<β-<(1,3-dioxolan-2-yl)methyl>-α-oxobutyl>oxazolidin-2-one

Base Information

Chemical Name:-4-benzyl-3-<β-<(1,3-dioxolan-2-yl)methyl>-α-oxobutyl>oxazolidin-2-one
CAS No.:130710-58-6
Molecular Formula:C₁₈H₂₃NO₅
Molecular Weight:333.384
Hs Code.:

<S-(R*,S*)>-4-benzyl-3-<β-<(1,3-dioxolan-2-yl)methyl>-α-oxobutyl>oxazolidin-2-one

Synonyms:-4-benzyl-3-<β-<(1,3-dioxolan-2-yl)methyl>-α-oxobutyl>oxazolidin-2-one

Suppliers and Price of -4-benzyl-3-<β-<(1,3-dioxolan-2-yl)methyl>-α-oxobutyl>oxazolidin-2-one

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Chemical Property of -4-benzyl-3-<β-<(1,3-dioxolan-2-yl)methyl>-α-oxobutyl>oxazolidin-2-one

Chemical Property:

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Technology Process of -4-benzyl-3-<β-<(1,3-dioxolan-2-yl)methyl>-α-oxobutyl>oxazolidin-2-one

There total 4 articles about -4-benzyl-3-<β-<(1,3-dioxolan-2-yl)methyl>-α-oxobutyl>oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 130710-57-5
-4-benzyl-β-ethyl-γ,2-dioxo-oxazolidine-3-butanal

: 107-21-1
ethylene glycol

: 130710-58-6
-4-benzyl-3-<β-<(1,3-dioxolan-2-yl)methyl>-α-oxobutyl>oxazolidin-2-one

Guidance literature:: With 4 A molecular sieve; toluene-4-sulfonic acid; In benzene; for 4.5h; Heating;

Reference yield:

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 130710-58-6
-4-benzyl-3-<β-<(1,3-dioxolan-2-yl)methyl>-α-oxobutyl>oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 1.6 m butyl-lithium / 2,2'-dipyridyl / 1.) THF, hexane, -78 deg C, 10 min, 2.) -78 deg C, 45 min, --> room temperature, 45 min

2: 1.) LDA / 1.) hexane, THF, -78 deg C, 45 min, 2.) -78 deg C --> room temperature, 2.5 h

3: 1.) ozone, 2.) triphenylphosphine / 1.) dichloromethane, -78 deg C, 1.5 h, 2.) -78 deg C, 30 min, --> room temperature, 2 h

4: 85 percent / toluene-p-sulphonic acid monohydrate, 4 Angstroem molecular sieves / benzene / 4.5 h / Heating

With n-butyllithium; 4 A molecular sieve; toluene-4-sulfonic acid; ozone; triphenylphosphine; lithium diisopropyl amide; [2,2]bipyridinyl; In benzene;

Reference yield:

: 111292-87-6,143097-11-4,112459-79-7
(S)-4-benzyl-3-butyryloxazolidin-2-one

: 130710-58-6
-4-benzyl-3-<β-<(1,3-dioxolan-2-yl)methyl>-α-oxobutyl>oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) hexane, THF, -78 deg C, 45 min, 2.) -78 deg C --> room temperature, 2.5 h

2: 1.) ozone, 2.) triphenylphosphine / 1.) dichloromethane, -78 deg C, 1.5 h, 2.) -78 deg C, 30 min, --> room temperature, 2 h

3: 85 percent / toluene-p-sulphonic acid monohydrate, 4 Angstroem molecular sieves / benzene / 4.5 h / Heating

With 4 A molecular sieve; toluene-4-sulfonic acid; ozone; triphenylphosphine; lithium diisopropyl amide; In benzene;