benzyl (1-(benzyloxy)-3-(biphenyl-4-yl)-1H-pyrazol-4-yl)methylcarbamate

Base Information

Chemical Name:benzyl (1-(benzyloxy)-3-(biphenyl-4-yl)-1H-pyrazol-4-yl)methylcarbamate
CAS No.:1421357-28-9
Molecular Formula:C₃₁H₂₇N₃O₃
Molecular Weight:489.574
Hs Code.:

Synonyms:benzyl (1-(benzyloxy)-3-(biphenyl-4-yl)-1H-pyrazol-4-yl)methylcarbamate

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Chemical Property of benzyl (1-(benzyloxy)-3-(biphenyl-4-yl)-1H-pyrazol-4-yl)methylcarbamate

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Technology Process of benzyl (1-(benzyloxy)-3-(biphenyl-4-yl)-1H-pyrazol-4-yl)methylcarbamate

There total 4 articles about benzyl (1-(benzyloxy)-3-(biphenyl-4-yl)-1H-pyrazol-4-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1421357-20-1
benzyl ((1-(benzyloxy)-3-iodo-1H-pyrazol-4-yl)methyl)carbamate

: 5122-94-1
4-biphenylboronic acid

: 1421357-28-9
benzyl (1-(benzyloxy)-3-(biphenyl-4-yl)-1H-pyrazol-4-yl)methylcarbamate

Guidance literature:: With bis(diphenylphosphino)palladium(II)dichloride; potassium carbonate; In ethanol; water; toluene; at 100 ℃; for 20h;
DOI:10.1021/jm301473k

Reference yield:

: 229171-07-7
1-(benzyloxy)-4-iodo-1H-pyrazole

: 1421357-28-9
benzyl (1-(benzyloxy)-3-(biphenyl-4-yl)-1H-pyrazol-4-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: isopropylmagnesium chloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 18.5 h / 0 - 20 °C / Inert atmosphere

3: Iodine monochloride / water; acetic acid / 23 h / 85 °C

4: potassium carbonate; bis(diphenylphosphino)palladium(II)dichloride / water; toluene; ethanol / 20 h / 100 °C

With sodium tetrahydroborate; bis(diphenylphosphino)palladium(II)dichloride; nickel(II) chloride hexahydrate; isopropylmagnesium chloride; Iodine monochloride; potassium carbonate; In tetrahydrofuran; methanol; ethanol; water; acetic acid; toluene;
DOI:10.1021/jm301473k

Reference yield:

: 1-benzyloxy-1H-pyrazole-4-carbonitrile

: 1421357-28-9
benzyl (1-(benzyloxy)-3-(biphenyl-4-yl)-1H-pyrazol-4-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 18.5 h / 0 - 20 °C / Inert atmosphere

2: Iodine monochloride / water; acetic acid / 23 h / 85 °C

3: potassium carbonate; bis(diphenylphosphino)palladium(II)dichloride / water; toluene; ethanol / 20 h / 100 °C

With sodium tetrahydroborate; bis(diphenylphosphino)palladium(II)dichloride; nickel(II) chloride hexahydrate; Iodine monochloride; potassium carbonate; In methanol; ethanol; water; acetic acid; toluene;
DOI:10.1021/jm301473k