(R)-6-bromo-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Base Information

Chemical Name:(R)-6-bromo-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one
CAS No.:1613721-50-8
Molecular Formula:C₁₇H₁₃BrFN₃O₂
Molecular Weight:390.212
Hs Code.:

Synonyms:(R)-6-bromo-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

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Chemical Property of (R)-6-bromo-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

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Technology Process of (R)-6-bromo-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

There total 2 articles about (R)-6-bromo-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613721-88-2
(R)-2-(7-bromo-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propionic acid ethyl ester

: 1613721-50-8
(R)-6-bromo-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: Lawessons reagent / toluene / 3 h / Reflux

2: hydrazine hydrate / ethanol / 20 °C

3: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate / water; 1,4-dioxane / 2 h / 90 °C

4: trifluoroacetic acid; N-Bromosuccinimide / 3 h / 20 °C

With Lawessons reagent; N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; In 1,4-dioxane; ethanol; water; toluene;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-89-3
(R)-2-(7-bromo-3-thioxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propionic acid ethyl ester

: 1613721-50-8
(R)-6-bromo-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 20 °C

2: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate / water; 1,4-dioxane / 2 h / 90 °C

3: trifluoroacetic acid; N-Bromosuccinimide / 3 h / 20 °C

With N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jm5013006

Reference yield: 65.0%

: 212127-83-8
tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-dihydropyrrole-1-carboxylate

: 1613721-50-8
(R)-6-bromo-7-(2-fluorophenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

: 3-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 15h;
DOI:10.1021/jm5013006