N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Base Information

Chemical Name:N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
CAS No.:1402598-88-2
Molecular Formula:C₃₂H₂₆ClF₃N₂O₅S₂
Molecular Weight:675.149
Hs Code.:

N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Synonyms:N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

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Chemical Property of N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

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Technology Process of N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

There total 8 articles about N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402599-20-5
(2S)-2-(2-(2-((R)-amino(2-chlorophenyl)methyl)-1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1-trifluoro-2-propanol

: 321309-38-0
3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonyl chloride

: 1402598-88-2
N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 23794-15-2
1-(2-chloropyridin-4-yl)ethan-1-one

: 1402598-88-2
N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: cesium fluoride / 1,2-dimethoxyethane / -78 - 20 °C

1.2: 20 h / 20 °C

2.1: Chiralcel^.(R). OJ- H column / isopropyl alcohol; hexane; carbon dioxide / Resolution of racemate

3.1: XPhos; sodium carbonate monohydrate / bis(η3-allyl-μ-chloropalladium(II)) / 1,4-dioxane; water / 21 h / 20 - 80 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

4.2: -78 °C

5.1: hydrogenchloride / diethyl ether / 6 h / 20 °C

6.1: dmap; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; dmap; n-butyllithium; sodium carbonate monohydrate; N-ethyl-N,N-diisopropylamine; cesium fluoride; XPhos; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; diethyl ether; hexane; carbon dioxide; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1402599-08-9
2-(2-chloro-4-pyridinyl)-1,1,1-trifluoro-2-propanol

: 1402598-88-2
N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Chiralcel^.(R). OJ- H column / isopropyl alcohol; hexane; carbon dioxide / Resolution of racemate

2.1: XPhos; sodium carbonate monohydrate / bis(η3-allyl-μ-chloropalladium(II)) / 1,4-dioxane; water / 21 h / 20 - 80 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

3.2: -78 °C

4.1: hydrogenchloride / diethyl ether / 6 h / 20 °C

5.1: dmap; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; dmap; n-butyllithium; sodium carbonate monohydrate; N-ethyl-N,N-diisopropylamine; XPhos; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; carbon dioxide; water; N,N-dimethyl-formamide; isopropyl alcohol;