dimethyl 2-(but-2-yn-1-yl)-2-((1-(4-chlorobenzyl)-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate

Base Information

Chemical Name:dimethyl 2-(but-2-yn-1-yl)-2-((1-(4-chlorobenzyl)-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate
CAS No.:1437300-21-4
Molecular Formula:C₂₃H₂₆ClNO₄
Molecular Weight:415.917
Hs Code.:

Synonyms:dimethyl 2-(but-2-yn-1-yl)-2-((1-(4-chlorobenzyl)-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate

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Chemical Property of dimethyl 2-(but-2-yn-1-yl)-2-((1-(4-chlorobenzyl)-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate

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Technology Process of dimethyl 2-(but-2-yn-1-yl)-2-((1-(4-chlorobenzyl)-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate

There total 3 articles about dimethyl 2-(but-2-yn-1-yl)-2-((1-(4-chlorobenzyl)-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 107428-05-7
dimethyl 2,2-di(but-2-yn-1-yl)malonate

: 188818-08-8
1-p-chlorobenzyl-2-methyleneaziridine

: 1437300-21-4
dimethyl 2-(but-2-yn-1-yl)-2-((1-(4-chlorobenzyl)-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate

Guidance literature:: With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; In 1,4-dioxane; at 20 ℃; regioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1039/c3cc41061g

Reference yield:

: 1178438-59-9
C₁₀H₁₁BrClN

: 1437300-21-4
dimethyl 2-(but-2-yn-1-yl)-2-((1-(4-chlorobenzyl)-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia; sodium amide / diethyl ether / 1 h / -78 °C

2: bis(1,5-cyclooctadiene)nickel⁽⁰⁾ / 1,4-dioxane / 20 °C / Inert atmosphere; Schlenk technique

With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; ammonia; sodium amide; In 1,4-dioxane; diethyl ether;
DOI:10.1039/c3cc41061g

Reference yield:

: 104-86-9
4-chlorobenzylamine

: 1437300-21-4
dimethyl 2-(but-2-yn-1-yl)-2-((1-(4-chlorobenzyl)-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

2: ammonia; sodium amide / diethyl ether / 1 h / -78 °C

3: bis(1,5-cyclooctadiene)nickel⁽⁰⁾ / 1,4-dioxane / 20 °C / Inert atmosphere; Schlenk technique

With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; ammonia; potassium carbonate; sodium amide; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1039/c3cc41061g