ethyl 2-(4-trifluoromethyldiaziridinylphenyl)hydrazine carboxylate

Base Information

• Chemical Name: ethyl 2-(4-trifluoromethyldiaziridinylphenyl)hydrazine carboxylate
• CAS No.: 236386-32-6
• Molecular Formula: C₁₁H₁₃F₃N₄O₂
• Molecular Weight: 290.245
• Mol file: 236386-32-6.mol

Synonyms:ethyl 2-(4-trifluoromethyldiaziridinylphenyl)hydrazine carboxylate

Chemical Property of ethyl 2-(4-trifluoromethyldiaziridinylphenyl)hydrazine carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 2-(4-trifluoromethyldiaziridinylphenyl)hydrazine carboxylate

There total 5 articles about ethyl 2-(4-trifluoromethyldiaziridinylphenyl)hydrazine carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

ethyl 2-(4-trifluoroacetyltosyloximephenyl)hydrazinecarboxylate (236386-30-4) → ethyl 2-(4-trifluoromethyldiaziridinylphenyl)hydrazine carboxylate (236386-32-6)

Guidance literature:

With ammonia; In diethyl ether; at -78 ℃; for 4h;

DOI:10.1021/ja990351h

Reference yield:

2,2,2-trifluoro-1-(4-fluorophenyl)ethanone (655-32-3) → ethyl 2-(4-trifluoromethyldiaziridinylphenyl)hydrazine carboxylate (236386-32-6)

Guidance literature:

Multi-step reaction with 5 steps

1: NH₂NH₂ / dimethylsulfoxide / 1 h / 90 °C

2: pyridine / acetonitrile / 0.17 h

3: 98 percent / NH₂OH*HCl, pyridine / ethanol / 2 h / Heating

4: 58 percent / Et₃N / acetone / 0.17 h

5: 7 percent / NH₃ liq. / diethyl ether / 4 h / -78 °C

With pyridine; hydroxylamine hydrochloride; ammonia; triethylamine; hydrazine; In diethyl ether; ethanol; dimethyl sulfoxide; acetone; acetonitrile;

DOI:10.1021/ja990351h

Reference yield:

4-trifluoroacetylphenylhydrazine (350040-14-1) → ethyl 2-(4-trifluoromethyldiaziridinylphenyl)hydrazine carboxylate (236386-32-6)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / acetonitrile / 0.17 h

2: 98 percent / NH₂OH*HCl, pyridine / ethanol / 2 h / Heating

3: 58 percent / Et₃N / acetone / 0.17 h

4: 7 percent / NH₃ liq. / diethyl ether / 4 h / -78 °C

With pyridine; hydroxylamine hydrochloride; ammonia; triethylamine; In diethyl ether; ethanol; acetone; acetonitrile;

DOI:10.1021/ja990351h

upstream raw materials:

ethyl 2-(4-trifluoroacetyltosyloximephenyl)hydrazinecarboxylate

2,2,2-trifluoro-1-(4-fluorophenyl)ethanone

4-trifluoroacetylphenylhydrazine

ethyl 2-(4-trifluoroacetylphenyl)hydrazinecarboxylate