5-amino-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile

Base Information

• Chemical Name: 5-amino-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile
• CAS No.: 1000815-86-0
• Molecular Formula: C₁₁H₅ClF₄N₄
• Molecular Weight: 304.634
• Mol file: 1000815-86-0.mol

Synonyms:5-amino-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile

Chemical Property of 5-amino-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-amino-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile

There total 4 articles about 5-amino-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-chloro-6-fluoro-4-(trifluoromethyl)aniline + 1,2-dicyano-3-hydroxyprop-2-ene (150006-50-1) → 5-amino-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile (1000815-86-0)

Guidance literature:

2-chloro-6-fluoro-4-(trifluoromethyl)aniline; With sulfuric acid; acetic acid; sodium nitrite; at 0 - 50 ℃; for 1h;

1,2-dicyano-3-hydroxyprop-2-ene; With sodium acetate; In water; at 5 - 10 ℃; for 1h;

Reference yield: 71.0%

2-chloro-6-fluoro-4-(trifluoromethyl)aniline + (E,Z)-2-formylsuccinonitrile potassium salt (89283-73-8) → 5-amino-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile (1000815-86-0)

Guidance literature:

2-chloro-6-fluoro-4-(trifluoromethyl)aniline; With nitrosylsulfuric acid; In acetic acid; at 15 ℃; for 1h;

(E,Z)-2-formylsuccinonitrile potassium salt; With sodium acetate; In water; acetic acid; at 7 ℃; for 1h;

With ammonia; In dichloromethane; water; acetic acid;

Reference yield:

2-fluoro-4-(trifluoromethyl)aniline (69409-98-9) → 5-amino-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile (1000815-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / acetonitrile / 3 h / Reflux

2.1: acetic acid; sulfuric acid; sodium nitrite / 1 h / 0 - 50 °C

2.2: 1 h / 5 - 10 °C

With N-chloro-succinimide; sulfuric acid; acetic acid; sodium nitrite; In acetonitrile;

upstream raw materials:

(E,Z)-2-formylsuccinonitrile potassium salt

2-fluoro-4-(trifluoromethyl)benzoic acid

2-fluoro-4-(trifluoromethyl)aniline

1,2-dicyano-3-hydroxyprop-2-ene

Downstream raw materials:

5-bromo-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylsulfinyl)-1H-pyrazole-3-carbonitrile

5-amino-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylsulfinyl)-1H-pyrazole-3-carbonitrile

5-amino-3-cyano-1-(2-chloro-6-fluoro-4-trifluoromethylphenyl)-4-trifluoro-methylthiopyrazole