1-bromobenzyl-3-[3-tert-butylsulfanyl-5-(methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester

Base Information

• Chemical Name: 1-bromobenzyl-3-[3-tert-butylsulfanyl-5-(methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester
• CAS No.: 1031435-50-3
• Molecular Formula: C₂₇H₃₄BrNO₃S
• Molecular Weight: 532.542
• Mol file: 1031435-50-3.mol

Synonyms:1-bromobenzyl-3-[3-tert-butylsulfanyl-5-(methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester

Chemical Property of 1-bromobenzyl-3-[3-tert-butylsulfanyl-5-(methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester

Chemical Property:

• Boiling Point: 618.2±55.0 °C(Predicted)
• Density: 1.22±0.1 g/cm3(Predicted)

Purity/Quality:

Ethyl3-(1-(4-(bromomethyl)benzyl)-3-(tert-butylthio)-5-methoxy-1H-indol-2-yl)-2,2-dimethylpropanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-bromobenzyl-3-[3-tert-butylsulfanyl-5-(methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester

There total 3 articles about 1-bromobenzyl-3-[3-tert-butylsulfanyl-5-(methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1-(4-methoxyphenyl)-1-bromobenzylhydrazine dihydrochloride + ethyl 5-t-butylthio-2,2-dimethyl-4-oxo-pentanoate (136558-13-9) → 1-bromobenzyl-3-[3-tert-butylsulfanyl-5-(methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester (1031435-50-3)

Guidance literature:

With sodium acetate; acetic acid; In toluene; at 20 ℃; for 96h; Inert atmosphere;

DOI:10.1021/jm900945d

Reference yield: 55.0%

ethyl 5-t-butylthio-2,2-dimethyl-4-oxo-pentanoate (136558-13-9) + N-(4-bromobenzyl)-N-(4-methoxyphenyl)-hydrazine (176045-80-0) → 1-bromobenzyl-3-[3-tert-butylsulfanyl-5-(methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester (1031435-50-3)

Guidance literature:

With sodium acetate; acetic acid; In toluene; at 20 ℃;

DOI:10.1016/j.bmcl.2010.06.011

Reference yield: 50.0%

1-[4-bromobenzyl]-1-(4-methoxy phenyl)-hydrazine hydrochloride + ethyl 5-t-butylthio-2,2-dimethyl-4-oxo-pentanoate (136558-13-9) → 1-bromobenzyl-3-[3-tert-butylsulfanyl-5-(methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester (1031435-50-3)

Guidance literature:

With sodium acetate; In acetic acid; toluene; at 20 ℃; for 96h;

upstream raw materials:

ethyl 5-t-butylthio-2,2-dimethyl-4-oxo-pentanoate

N-(4-bromobenzyl)-N-(4-methoxyphenyl)-hydrazine

Downstream raw materials:

3-[1-(4-bromo-benzyl)-3-tert-butylsulfanyl-5-hydroxy-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester