3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid p-tolylamide

Base Information

• Chemical Name: 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid p-tolylamide
• CAS No.: 345912-45-0
• Molecular Formula: C₂₄H₂₀ClN₃OS
• Molecular Weight: 433.961

Synonyms:3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid p-tolylamide

Chemical Property of 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid p-tolylamide

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Technology Process of 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid p-tolylamide

There total 4 articles about 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid p-tolylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-[4-(4-chloro-phenyl)-3-cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-N-p-tolyl-acetamide (345912-33-6) → 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid p-tolylamide (345912-45-0)

Guidance literature:

With sodium ethanolate; In ethanol; for 0.0833333h; Heating;

DOI:10.1080/10426500008076538

Reference yield:

(E)-2-(4-chlorobenzylidene)cyclopentan-1-one (134791-44-9) → 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid p-tolylamide (345912-45-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / NaOMe / methanol / 48 h / 50 °C

2: 81 percent / AcONa*3H₂O / ethanol / 2 h / Heating

3: 90 percent / EtONa / ethanol / 0.08 h / Heating

With sodium methylate; sodium ethanolate; sodium acetate; In methanol; ethanol; 3: Thorpe-Ziegler cyclization;

DOI:10.1080/10426500008076538

Reference yield:

4-<4-chlorophenyl>-3-cyano-5,6-trimethylenepyridine-2<1H>-thione (83236-50-4) → 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid p-tolylamide (345912-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / AcONa*3H₂O / ethanol / 2 h / Heating

2: 90 percent / EtONa / ethanol / 0.08 h / Heating

With sodium ethanolate; sodium acetate; In ethanol; 2: Thorpe-Ziegler cyclization;

DOI:10.1080/10426500008076538

upstream raw materials:

4-<4-chlorophenyl>-3-cyano-5,6-trimethylenepyridine-2<1H>-thione

N-(p-tolyl)-2-chloroacetamide

2-[4-(4-chloro-phenyl)-3-cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-N-p-tolyl-acetamide

(E)-2-(4-chlorobenzylidene)cyclopentan-1-one

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