83236-50-4

Upstream product

• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 1687-46-3 cyclopentane-1,1-dithiol 
• 83236-47-9 7-Amino-9-(4-chloro-phenyl)-6,10-dithia-spiro[4.5]dec-7-ene-8-carbonitrile 
• 7357-70-2 Cyanothioacetamide 
• 134791-44-9 (E)-2-(4-chlorobenzylidene)cyclopentan-1-one 
• 936-52-7 1-(N-morpholino)cyclopent-1-ene 
• 102423-75-6 2,6-diamino-4-(4-chlorophenyl)-4H-thiopyran-3,5-dicarbonitrile 

Downstream Products

• 345912-24-5 4-(4-chloro-phenyl)-2-cyanomethylsulfanyl-6,7-dihydro-5H-[1]pyrindine-3-carbonitrile 
• 345912-36-9 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carbonitrile 
• 345912-31-4 2-[4-(4-chloro-phenyl)-3-cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-N-phenyl-acetamide 
• 345912-43-8 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid phenylamide 
• 345912-33-6 2-[4-(4-chloro-phenyl)-3-cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-N-p-tolyl-acetamide 
• 345912-45-0 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid p-tolylamide 
• 345912-32-5 N-(4-chloro-phenyl)-2-[4-(4-chloro-phenyl)-3-cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide 
• 536720-16-8 [4-(4-chloro-phenyl)-3-cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetic acid ethyl ester 
• 434293-29-5 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid ethyl ester 
• 488824-03-9 2-methoxycarbonylmethylsulfanyl-4-(4-chlorophenyl)-6,7-dihydro-5H-[1]pyrindine-3-carbonitrile 
• 1414778-34-9 ethyl 6-({[4-(4-chlorophenyl)-3-cyano-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]thio}methyl)-4-(4-methoxyphenyl)-1-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1414778-32-7 ethyl 4-(4-bromophenyl)-6-({[4-(4-chlorophenyl)-3-cyano-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]thio}methyl)-1-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Cross-recyclization of 4-aryl-2,6-diamino-4H-thiopyran-3,5-dicarbonitriles with 1-morpholino-1-cyclopentene: New route to 4-aryl-2-thioxo-2,5,6,7- tetrahydro-1H-[1]pyrindine-3-carbonitriles and their derivatives

Reaction of 4-aryl-2,6-diamino-4H-thiopyran-3,5-dicarbonitriles with 1-morpholino-1-cyclopentene led to the formation of 4-aryl-2-thioxo-2,5,6,7- tetrahydro-1H-[1]pyrindine-3-carbonitriles used in the synthesis of substituted 2-alkylsulfanyl-4-aryl-6,7-di

Synthesis of some new thieno[2,3-b]pyridines, pyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidines and pyrido[3′,2′:4,5]thieno[3,2-d][1,2,3]-triazines

4-Aryl-3-cyano-2-substituted-methylthiocyclopenta[b]pyridines (3a-c and 4a-i) were prepared by reaction of 4-aryl-3-cyanocyclopenta[b]pyridine-2(1H)-thiones(2a-c) with chloroacetonitrile or chloro-N-arylacelamides, respectively. On treatment of these products with sodium ethoxide in boiling ethanol, they underwent intramolecular Thorpe-Ziegler cyclization to afford the corresponding 3-amino-4-aryl-2-functionallized-cyclopenta[e]thieno [2,3-b]pyridines (5a-c and 6a-i). Most of the latter thienopyridines were used as synthons for the target cyclopenta[5′,6′]pyrido[3′,2′:4,5]thieno[3,2-d] pyrimidines and cyclopenta[5′,6′] pyrido[3′,2′:4,5]thieno[3,2-d)[1,2,3]triazines.

CYCLIZATION OF NITRILES. X. ENAMINO NITRILES OF THE 1,3-DITHIA-4-CYCLOHEXENE SERIES AND THEIR RECYCLIZATION TO DERIVATIVES OF PYRIDINE AND THIAZOLE

The recyclization of 4-amino-6-aryl-5-cyano-2-cyclopentane(cyclohexane)spiro-1,3-dithia-4-cyclohexenes, obtained from gem-dithiols and arylidenemalononitriles, leads to the formation of 4-aryl-5,6-polymethylene-3-cyano-2-(1H)-pyridinethiones.The latter are used in the synthesis of various 3-aminothienopyridines, 4-aryl-3-amino-5,6,7,8-tetrahydrothienoquinolines, and other heterocyclic compounds condensed with quinoline. 1-Cyano-1-(4-aryl-2-thiazolyl)-2-arylethylenes were obtained by the reaction of the 1,3-dithia-4-cyclohexenes with phenacyl bromides.