2-((difluoro(phenyl)methyl)sulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole

Base Information

Chemical Name:2-((difluoro(phenyl)methyl)sulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole
CAS No.:1443114-40-6
Molecular Formula:C₂₃H₁₈F₂N₂O₂S
Molecular Weight:424.471
Hs Code.:

Synonyms:2-((difluoro(phenyl)methyl)sulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole

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Chemical Property of 2-((difluoro(phenyl)methyl)sulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole

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Technology Process of 2-((difluoro(phenyl)methyl)sulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole

There total 10 articles about 2-((difluoro(phenyl)methyl)sulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1443114-24-6
2-(benzylsulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole

: 1443114-40-6
2-((difluoro(phenyl)methyl)sulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole

Guidance literature:: 2-(benzylsulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at 0 ℃; for 0.5h; Further stages; Inert atmosphere;
DOI:10.1021/ml400166b

Reference yield: 52.0%

: 1443114-24-6
2-(benzylsulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole

: 1443114-39-3
2-((fluoro(phenyl)methyl)sulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole

: 1443114-40-6
2-((difluoro(phenyl)methyl)sulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole

Guidance literature:: 2-(benzylsulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ml400166b

Reference yield:

: 2349-58-8
4,5-diphenyl-1H-imidazole-2-thiol

: 1443114-40-6
2-((difluoro(phenyl)methyl)sulfonyl)-1-methyl-4,5-diphenyl-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

2.1: caesium carbonate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.2: 0.5 h / 0 °C / Inert atmosphere

With potassium tert-butylate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml400166b